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Details for receptor: PDGFR

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EndoNet ID: ENR01178

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Synonyms

  • PDGFR
  • PDGFRalpha:PDGFRbeta

General information

  • PDGF A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. [1]
  • PDGF is the most potent mitogen for HSCs in vitro.

Links to other resources

Subunit information

PDGFR-beta (1 times)

Sequence 
LVVTPPGPE LVLNVSSTF VLTCSGSAP 
VVWERMSQE PPQEMAKAQ DGTFSSVLT 
LTNLTGLDT GEYFCTHND SRGLETDER 
KRLYIFVPD PTVGFLPND AEELFIFLT 
EITEITIPC RVTDPQLVV TLHEKKGDV 
ALPVPYDHQ RGFSGIFED RSYICKTTI 
GDREVDSDA YYVYRLQVS SINVSVNAV 
QTVVRQGEN ITLMCIVIG NEVVNFEWT 
YPRKESGRL VEPVTDFLL DMPYHIRSI 
LHIPSAELE DSGTYTCNV TESVNDHQD 
EKAINITVV ESGYVRLLG EVGTLQFAE 
LHRSRTLQV VFEAYPPPT VLWFKDNRT 
LGDSSAGEI ALSTRNVSE TRYVSELTL 
VRVKVAEAG HYTMRAFHE DAEVQLSFQ 
LQINVPVRV LELSESHPD SGEQTVRCR 
GRGMPQPNI IWSACRDLK RCPRELPPT 
LLGNSSEEE SQLETNVTY WEEEQEFEV 
VSTLRLQHV DRPLSVRCT LRNAVGQDT 
QEVIVVPHS LPFKVVVIS AILALVVLT 
IISLIILIM LWQKKPRYE IRWKVIESV 
SSDGHEYIY VDPMQLPYD STWELPRDQ 
LVLGRTLGS GAFGQVVEA TAHGLSHSQ 
ATMKVAVKM LKSTARSSE KQALMSELK 
IMSHLGPHL NVVNLLGAC TKGGPIYII 
TEYCRYGDL VDYLHRNKH TFLQHHSDK 
RRPPSAELY SNALPVGLP LPSHVSLTG 
ESDGGYMDM SKDESVDYV PMLDMKGDV 
KYADIESSN YMAPYDNYV PSAPERTCR 
ATLINESPV LSYMDLVGF SYQVANGME 
FLASKNCVH RDLAARNVL ICEGKLVKI 
CDFGLARDI MRDSNYISK GSTFLPLKW 
MAPESIFNS LYTTLSDVW SFGILLWEI 
FTLGGTPYP ELPMNEQFY NAIKRGYRM 
AQPAHASDE IYEIMQKCW EEKFEIRPP 
FSQLVLLLE RLLGEGYKK KYQQVDEEF 
LRSDHPAIL RSQARLPGF HGLRSPLDT 
SSVLYTAVQ PNEGDNDYI IPLPDPKPE 
VADEGPLEG SPSLASSTL NEVNTSSTI 
SCDSPLEPQ DEPEPEPQL ELQVEPEPE 
LEQLPDSGC PAPRAEAED SFL
UniProt P09619

PDGFR-alpha (1 times)

Sequence 
QLSLPSILP NENEKVVQL NSSFSLRCF 
GESEVSWQY PMSEEESSD VEIRNEENN 
SGLFVTVLE VSSASAAHT GLYTCYYNH 
TQTEENELE GRHIYIYVP DPDVAFVPL 
GMTDYLVIV EDDDSAIIP CRTTDPETP 
VTLHNSEGV VPASYDSRQ GFNGTFTVG 
PYICEATVK GKKFQTIPF NVYALKATS 
ELDLEMEAL KTVYKSGET IVVTCAVFN 
NEVVDLQWT YPGEVKGKG ITMLEEIKV 
PSIKLVYTL TVPEATVKD SGDYECAAR 
QATREVKEM KKVTISVHE KGFIEIKPT 
FSQLEAVNL HEVKHFVVE VRAYPPPRI 
SWLKNNLTL IENLTEITT DVEKIQEIR 
YRSKLKLIR AKEEDSGHY TIVAQNEDA 
VKSYTFELL TQVPSSILD LVDDHHGST 
GGQTVRCTA EGTPLPDIE WMICKDIKK 
CNNETSWTI LANNVSNII TEIHSRDRS 
TVEGRVTFA KVEETIAVR CLAKNLLGA 
ENRELKLVA PTLRSELTV AAAVLVLLV 
IVIISLIVL VVIWKQKPR YEIRWRVIE 
SISPDGHEY IYVDPMQLP YDSRWEFPR 
DGLVLGRVL GSGAFGKVV EGTAYGLSR 
SQPVMKVAV KMLKPTARS SEKQALMSE 
LKIMTHLGP HLNIVNLLG ACTKSGPIY 
IITEYCFYG DLVNYLHKN RDSFLSHHP 
EKPKKELDI FGLNPADES TRSYVILSF 
ENNGDYMDM KQADTTQYV PMLERKEVS 
KYSDIQRSL YDRPASYKK KSMLDSEVK 
NLLSDDNSE GLTLLDLLS FTYQVARGM 
EFLASKNCV HRDLAARNV LLAQGKIVK 
ICDFGLARD IMHDSNYVS KGSTFLPVK 
WMAPESIFD NLYTTLSDV WSYGILLWE 
IFSLGGTPY PGMMVDSTF YNKIKSGYR 
MAKPDHATS EVYEIMVKC WNSEPEKRP 
SFYHLSEIV ENLLPGQYK KSYEKIHLD 
FLKSDHPAV ARMRVDSDN AYIGVTYKN 
EEDKLKDWE GGLDEQRLS ADSGYIIPL 
PDIDPVPEE EDLGKRNRH SSQTSEESA 
IETGSSSST FIKREDETI EDIDMMDDI 
GIDSSDLVE DSFL
UniProt P16234-1

Binding hormones

  • PDGF
  • PDGFB

Anatomical structures with this receptor

  • lipocyte_of_liver

    Induced phenotypes

    • regulation of tissue remodeling
      • Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions. [2]
      • PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype. [3]
    • PDGFs form a family of dimeric isoforms inducing growth stimulation, chemotaxis, cell shape changes, and intracellular signaling in HSC from mouse, rat, or humans. [2]
Reference