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Details for receptor: neurokinin-2 receptor

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EndoNet ID: ENR01182

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Synonyms

  • neurokinin-2 receptor
  • neurokinin A receptor
  • NK-2 receptor
  • substance-K receptor
  • SKR
  • NK-2R
  • tachykinin receptor 2
  • neurokinin 2 receptor

General information

  • This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). [1]
  • It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. [1]
  • The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. [1]
  • Since neuropeptide K and neuropeptide gamma are extended versions of neurokinin A, they bind to the same receptor.

Links to other resources

UniProt P21452
Ensembl ENST00000414492

Subunit information

substance-K receptor

Sequence 
MGTCDIVTE ANISSGPES NTTGITAFS 
MPSWQLALW ATAYLALVL VAVTGNAIV 
IWIILAHRR MRTVTNYFI VNLALADLC 
MAAFNAAFN FVYASHNIW YFGRAFCYF 
QNLFPITAM FVSIYSMTA IAADRYMAI 
VHPFQPRLS APSTKAVIA GIWLVALAL 
ASPQCFYST VTMDQGATK CVVAWPEDS 
GGKTLLLYH LVVIALIYF LPLAVMFVA 
YSVIGLTLW RRAVPGHQA HGANLRHLQ 
AKKKFVKTM VLVVLTFAI CWLPYHLYF 
ILGSFQEDI YCHKFIQQV YLALFWLAM 
SSTMYNPII YCCLNHRFR SGFRLAFRC 
CPWVTPTKE DKLELTPTT SLSTRVNRC 
HTKETLFMA GDTAPSEAT SGEAGRPQD 
GSGLWFGYG LLAPTKTHV EI
UniProt P21452

Binding hormones

  • neuropeptide gamma
  • neuropeptide K
  • SP
  • neurokinin A
  • neuromedin-K

Anatomical structures with this receptor

    Reference