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Details for receptor: relaxin receptor 2

EndoNet ID: ENR01187

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Synonyms

  • leucine-rich repeat-containing G-protein coupled receptor 8
  • G-protein coupled receptor affecting testicular descent
  • G-protein coupled receptor 106
  • RXFP2
  • GPR106
  • LGR8
  • GREAT
  • relaxin family peptide receptor 2
  • relaxin receptor 2
  • relaxin/insulin-like family peptide receptor 2

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt Q8WXD0
Ensembl ENST00000380314

Subunit information

Relaxin receptor 2. (1 times)

Sequence
MIVFLVFKH LFSLRLITM FFLLHFIVL 
INVKDFALT QGSMITPSC QKGYFPCGN 
LTKCLPRAF HCDGKDDCG NGADEENCG 
DTSGWATIF GTVHGNANS VALTQECFL 
KQYPQCCDC KETELECVN GDLKSVPMI 
SNNVTLLSL KKNKIHSLP DKVFIKYTK 
LKKIFLQHN CIRHISRKA FFGLCNLQI 
LYLNHNCIT TLRPGIFKD LHQLTWLIL 
DDNPITRIS QRLFTGLNS LFFLSMVNN 
YLEALPKQM CAQMPQLNW VDLEGNRIK 
YLTNSTFLS CDSLTVLFL PRNQIGFVP 
EKTFSSLKN LGELDLSSN TITELSPHL 
FKDLKLLQK LNLSSNPLM YLHKNQFES 
LKQLQSLDL ERIEIPNIN TRMFQPMKN 
LSHIYFKNF RYCSYAPHV RICMPLTDG 
ISSFEDLLA NNILRIFVW VIAFITCFG 
NLFVIGMRS FIKAENTTH AMSIKILCC 
ADCLMGVYL FFVGIFDIK YRGQYQKYA 
LLWMESVQC RLMGFLAML STEVSVLLL 
TYLTLEKFL VIVFPFSNI RPGKRQTSV 
ILICIWMAG FLIAVIPFW NKDYFGNFY 
GKNGVCFPL YYDQTEDIG SKGYSLGIF 
LGVNLLAFL IIVFSYITM FCSIQKTAL 
QTTEVRNCF GREVAVANR FFFIVFSDA 
ICWIPVFVV KILSLFRVE IPDTMTSWI 
VIFFLPVNS ALNPILYTL TTNFFKDKL 
KQLLHKHQR KSIFKIKKK SLSTSIVWI 
EDSSSLKLG VLNKITLGD SIMKPVS
UniProt Q8WXD0

Binding hormones

  • relaxin-2 isoform 1
  • relaxin-1
  • insulin-like 3

Anatomical structures with this receptor

  • brain

  • kidney

  • muscle

  • testis

    Induced phenotypes

    • Cryptorchidism
      • Defects in relaxin receptor 2 are a cause of cryptorchidism; also known as impaired testicular descent. [1]
  • thyroid_gland

  • uterus

  • peripheral blood leukocytes

  • bone_marrow

Reference