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Details for receptor: ALCAM

EndoNet ID: ENR01191

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  • CD166
  • MEMD
  • cellular differentiation 166

General information

  • ALCAM is involved in cell differentiation and migration. [1]
  • ALCAM supports the development of hematopoietic progenitor cells and enhances the capillary tube formation of endothelial cells, suggesting that ALCAM is involved in both vasculogenesis and angiogenesis. [1]
  • Facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. [2]
  • Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. [3]
  • Binding of ALCAM to CD6 suggests that ALCAM may be involved in immune and/or inflammatory responses. [1]
  • ALCAM is a type I membrane protein that belongs to the Ig superfamily, and it has five extracellular variable type and constant type Ig domains and a single transmembrane domain. [1]
  • Ligand of CD6. [1]

Links to other resources

UniProt Q13740
Ensembl ENST00000389927

Binding hormones

  • sALCAM

Anatomical structures with this receptor

  • bone_marrow

  • hematopoietic_stem_cell

  • brain

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • keratinocyte

  • peripheral blood leukocytes

  • melanocyte

  • aorta

  • mesodermal_cell

  • neuron

  • monocyte

  • B-lymphocyte

  • T-lymphocyte