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Details for receptor: L-selectin

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EndoNet ID: ENR01194

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Synonyms

  • L-selectin

General information

  • by functioning as both an adhesion and signaling molecule, L-selectin contributes to both early adhesive events as well as the later stages of chemotaxis and cell migration. [1]

Links to other resources

UniProt P14151
Ensembl ENST00000236147

Subunit information

Sequence 
MIFPWKCQS TQRDLWNIF KLWGWTMLC 
CDFLAHHGT DCWTYHYSE KPMNWQRAR 
RFCRDNYTD LVAIQNKAE IEYLEKTLP 
FSRSYYWIG IRKIGGIWT WVGTNKSLT 
EEAENWGDG EPNNKKNKE DCVEIYIKR 
NKDAGKWND DACHKLKAA LCYTASCQP 
WSCSGHGEC VEIINNYTC NCDVGYYGP 
QCQFVIQCE PLEAPELGT MDCTHPLGN 
FSFSSQCAF SCSEGTNLT GIEETTCGP 
FGNWSSPEP TCQVIQCEP LSAPDLGIM 
NCSHPLASF SFTSACTFI CSEGTELIG 
KKKTICESS GIWSNPSPI CQKLDKSFS 
MIKEGDYNP LFIPVAVMV TAFSGLAFI 
IWLARRLKK GKKSKRSMN DPY

Binding hormones

  • soluble PSGL-1

Anatomical structures with this receptor

  • lymphocyte

    Induced phenotypes

    • lymphocyte migration into lymph node
      • dominant role of L-selectin in mediating lymphocyte migration to the peripheral lymph node [1]
      • L-selectin also supports lymphocyte migration to the mesenteric lymph nodes and Peyer's patches [1]
      • optimal wound healing was found to require the cooperative interactions of all three selectins and ICAM-1 [1]
    • wound healing
      • optimal wound healing was found to require the cooperative interactions of all three selectins and ICAM-1 [1]
    • The constitutive expression of L-selectin by naive lymphocytes ans peripheral node adhesins by high endothelial venules within peripheral lymph nodes mediates the continuous recirculation of lymphocytes between blood and lymph. [1]

  • leukocyte

    • The constitutive expression of L-selectin by naive lymphocytes ans peripheral node adhesins by high endothelial venules within peripheral lymph nodes mediates the continuous recirculation of lymphocytes between blood and lymph. [1]
Reference