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Details for receptor: leptin receptor isoform b

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EndoNet ID: ENR01205

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Synonyms

  • OB-Rb
  • leptin receptor isoform b
  • OB receptor isoform b
  • OB receptor
  • HuB219
  • Leptin receptor

General information

  • OB-Rb is expressed primarily in the hypothalamus. OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells. [1]
  • Although OB-Rb is expressed abundantly in the hypothalamus, it is also expressed in some other cell types including adipocytes. [2]

Links to other resources

UniProt P48357-1
Ensembl ENST00000431694

Subunit information

Sequence 
FNLSYPITP WRFKLSCMP PNSTYDYFL 
LPAGLSKNT SNSNGHYET AVEPKFNSS 
GTHFSNLSK TTFHCCFRS EQDRNCSLC 
ADNIEGKTF VSTVNSLVF QQIDANWNI 
QCWLKGDLK LFICYVESL FKNLFRNYN 
YKVHLLYVL PEVLEDSPL VPQKGSFQM 
VHCNCSVHE CCECLVPVP TAKLNDTLL 
MCLKITSGG VIFQSPLMS VQPINMVKP 
DPPLGLHME ITDDGNLKI SWSSPPLVP 
FPLQYQVKY SENSTTVIR EADKIVSAT 
SLLVDSILP GSSYEVQVR GKRLDGPGI 
WSDWSTPRV FTTQDVIYF PPKILTSVG 
SNVSFHCIY KKENKIVPS KEIVWWMNL 
AEKIPQSQY DVVSDHVSK VTFFNLNET 
KPRGKFTYD AVYCCNEHE CHHRYAELY 
VIDVNINIS CETDGYLTK MTCRWSTST 
IQSLAESTL QLRYHRSSL YCSDIPSIH 
PISEPKDCY LQSDGFYEC IFQPIFLLS 
GYTMWIRIN HSLGSLDSP PTCVLPDSV 
VKPLPPSSV KAEITINIG LLKISWEKP 
VFPENNLQF QIRYGLSGK EVQWKMYEV 
YDAKSKSVS LPVPDLCAV YAVQVRCKR 
LDGLGYWSN WSNPAYTVV MDIKVPMRG 
PEFWRIING DTMKKEKNV TLLWKPLMK 
NDSLCSVQR YVINHHTSC NGTWSEDVG 
NHTKFTFLW TEQAHTVTV LAINSIGAS 
VANFNLTFS WPMSKVNIV QSLSAYPLN 
SSCVIVSWI LSPSDYKLM YFIIEWKNL 
NEDGEIKWL RISSSVKKY YIHDHFIPI 
EKYQFSLYP IFMEGVGKP KIINSFTQD 
DIEKHQSDA GLYVIVPVI ISSSILLLG 
TLLISHQRM KKLFWEDVP NPKNCSWAQ 
GLNFQKPET FEHLFIKHT ASVTCGPLL 
LEPETISED ISVDTSWKN KDEMMPTTV 
VSLLSTTDL EKGSVCISD QFNSVNFSE 
AEGTEVTYE DESQRQPFV KYATLISNS 
KPSETGEEQ GLINSSVTK CFSSKNSPL 
KDSFSNSSW EIEAQAFFI LSDQHPNII 
SPHLTFSEG LDELLKLEG NFPEENNDK 
KSIYYLGVT SIKKRESGV LLTDKSRVS 
CPFPAPCLF TDIRVLQDS CSHFVENNI 
NLGTSSKKT FASYMPQFQ TCSTQTHKI 
MENKMCDLT V

Binding hormones

  • leptin

Anatomical structures with this receptor

  • hypothalamus

    Influences

    • negative orexin-B
      • Leptin inhibts the secretion of orexin
    • negative orexin-A
      • Leptin inhibits the secretion of orexin [3]

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Influences

    • positive endothelin-1
      • Leptin is able to upregulate ET-1 production in human umbilical vein endothelial cells. [4]

  • vascularendothelial_cell

    Induced phenotypes

    • positive regulation of vasodilation
      • Leptin is a vasodilator in the peripheral vasculature in vitro. [5]
      • Leptin mediates nitric oxide-dependent vasodilatation in rat superior superior mesenteric artery rings. [6]

  • fat_cell

    Influences

    • positive ANG-2
      • Leptin induces Ang-2 and no VEGF in cultured adipocytes. [2]

  • adipose_tissue

    Influences

    • negative leptin
      • Isoform b from leptin receptor is responsible for mediating the autoregulation of leptin expression in adipose tissue. [7]
      • Leptin receptor mediated autocrine suppression by leptin on its own expression in adipose tissue is likely to play an important role in regulating plasma leptin concentration. [7]
Reference