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Details for receptor: ROBO1

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EndoNet ID: ENR01209

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Synonyms

  • roundabout homolog 1
  • H-Robo-1
  • deleted in U twenty twenty
  • DUTT1
  • SAX3
  • ROBO1
  • roundabout receptor 1

General information

  • Interacts with ROBO2.
  • Activation of the slit receptor Robo silences the attractive effect of netrin-1, but not its growth-stimulatory effect, through direct binding of the cytoplasmic domain of Robo to that of the netrin receptor DCC. [1]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [2]
  • Defects in ROBO1 may be a cause of breast and lung cancer. [3]
  • Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. [4]

Links to other resources

UniProt Q9Y6N7
Ensembl ENST00000436010

Subunit information

ROBO1

Sequence 
QLIPDPEDV ERGNDHGTP IPTSDNDDN 
SLGYTGSRL RQEDFPPRI VEHPSDLIV 
SKGEPATLN CKAEGRPTP TIEWYKGGE 
RVETDKDDP RSHRMLLPS GSLFFLRIV 
HGRKSRPDE GVYVCVARN YLGEAVSHN 
ASLEVAILR DDFRQNPSD VMVAVGEPA 
VMECQPPRG HPEPTISWK KDGSPLDDK 
DERITIRGG KLMITYTRK SDAGKYVCV 
GTNMVGERE SEVAELTVL ERPSFVKRP 
SNLAVTVDD SAEFKCEAR GDPVPTVRW 
RKDDGELPK SRYEIRDDH TLKIRKVTA 
GDMGSYTCV AENMVGKAE ASATLTVQE 
PPHFVVKPR DQVVALGRT VTFQCEATG 
NPQPAIFWR REGSQNLLF SYQPPQSSS 
RFSVSQTGD LTITNVQRS DVGYYICQT 
LNVAGSIIT KAYLEVTDV IADRPPPVI 
RQGPVNQTV AVDGTFVLS CVATGSPVP 
TILWRKDGV LVSTQDSRI KQLENGVLQ 
IRYAKLGDT GRYTCIAST PSGEATWSA 
YIEVQEFGV PVQPPRPTD PNLIPSAPS 
KPEVTDVSR NTVTLSWQP NLNSGATPT 
SYIIEAFSH ASGSSWQTV AENVKTETS 
AIKGLKPNA IYLFLVRAA NAYGISDPS 
QISDPVKTQ DVLPTSQGV DHKQVQREL 
GNAVLHLHN PTVLSSSSI EVHWTVDQQ 
SQYIQGYKI LYRPSGANH GESDWLVFE 
VRTPAKNSV VIPDLRKGV NYEIKARPF 
FNEFQGADS EIKFAKTLE EAPSAPPQG 
VTVSKNDGN GTAILVSWQ PPPEDTQNG 
MVQEYKVWC LGNETRYHI NKTVDGSTF 
SVVIPFLVP GIRYSVEVA ASTGAGSGV 
KSEPQFIQL DAHGNPVSP EDQVSLAQQ 
ISDVVKQPA FIAGIGAAC WIILMVFSI 
WLYRHRKKR NGLTSTYAG IRKVPSFTF 
TPTVTYQRG GEAVSSGGR PGLLNISEP 
AAQPWLADT WPNTGNNHN DCSISCCTA 
GNGNSDSNL TTYSRPADC IANYNNQLD 
NKQTNLMLP ESTVYGDVD LSNKINEMK 
TFNSPNLKD GRFVNPSGQ PTPYATTQL 
IQSNLSNNM NNGSGDSGE KHWKPLGQQ 
KQEVAPVQY NIVEQNKLN KDYRANDTV 
PPTIPYNQS YDQNTGGSY NSSDRGSST 
SGSQGHKKG ARTPKVPKQ GGMNWADLL 
PPPPAHPPP HSNSEEYNI SVDESYDQE 
MPCPVPPAR MYLQQDELE EEEDERGPT 
PPVRGAASS PAAVSYSHQ STATLTPSP 
QEELQPMLQ DCPEETGHM QHQPDRRRQ 
PVSPPPPPR PISPPHTYG YISGPLVSD 
MDTDAPEEE EDEADMEVA KMQTRRLLL 
RGLEQTPAS SVGDLESSV TGSMINGWG 
SASEEDNIS SGRSSVSSS DGSFFTDAD 
FAQAVAAAA EYAGLKVAR RQMQDAAGR 
RHFHASQCP RPTSPVSTD SNMSAAVMQ 
KTRPAKKLK HQPGHLRRE TYTDDLPPP 
PVPPPAIKS PTAQSKTQL EVRPVVVPK 
LPSMDARTD RSSDRKGSS YKGREVLDG 
RQVVDMRTN PGDPREAQE QQNDGKGRG 
NKAAKRDLP PAKTHLIQE DILPYCRPT 
FPTSNNPRD PSSSSSMSS RGSGSRQRE 
QANVGRRNI AEMQVLGGY ERGEDNNEE 
LEETES
UniProt Q9Y6N7

Binding hormones

  • slit-1
  • slit-2 isoform 1 C-product
  • slit-3 isoform 1

Anatomical structures with this receptor

  • thymus

  • neutrophil_granulocyte

  • uterus

  • placenta

  • brain

  • spinal_cord

Reference