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Details for receptor: ROBO2

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR01210

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Synonyms

  • roundabout receptor 2
  • roundabout homolog 2
  • roundabout, axon guidance receptor, homolog 2
  • ROBO2

General information

  • Interacts with ROBO1.
  • Activation of the slit receptor Robo silences the attractive effect of netrin-1, but not its growth-stimulatory effect, through direct binding of the cytoplasmic domain of Robo to that of the netrin receptor DCC. [1]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [2]
  • Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. [3]

Links to other resources

UniProt Q9HCK4
Ensembl ENST00000403211

Subunit information

ROBO2

Sequence 
SRLRQEDFP PRIVEHPSD VIVSKGEPT 
TLNCKAEGR PTPTIEWYK DGERVETDK 
DDPRSHRML LPSGSLFFL RIVHGRRSK 
PDEGSYVCV ARNYLGEAV SRNASLEVA 
LLRDDFRQN PTDVVVAAG EPAILECQP 
PRGHPEPTI YWKKDKVRI DDKEERISI 
RGGKLMISN TRKSDAGMY TCVGTNMVG 
ERDSDPAEL TVFERPTFL RRPINQVVL 
EEEAVEFRC QVQGDPQPT VRWKKDDAD 
LPRGRYDIK DDYTLRIKK TMSTDEGTY 
MCIAENRVG KMEASATLT VRAPPQFVV 
RPRDQIVAQ GRTVTFPCE TKGNPQPAV 
FWQKEGSQN LLFPNQPQQ PNSRCSVSP 
TGDLTITNI QRSDAGYYI CQALTVAGS 
ILAKAQLEV TDVLTDRPP PIILQGPAN 
QTLAVDGTA LLKCKATGD PLPVISWLK 
EGFTFPGRD PRATIQEQG TLQIKNLRI 
SDTGTYTCV ATSSSGETS WSAVLDVTE 
SGATISKNY DLSDLPGPP SKPQVTDVT 
KNSVTLSWQ PGTPGTLPA SAYIIEAFS 
QSVSNSWQT VANHVKTTL YTVRGLRPN 
TIYLFMVRA INPQGLSDP SPMSDPVRT 
QDISPPAQG VDHRQVQKE LGDVLVRLH 
NPVVLTPTT VQVTWTVDR QPQFIQGYR 
VMYRQTSGL QATSSWQNL DAKVPTERS 
AVLVNLKKG VTYEIKVRP YFNEFQGMD 
SESKTVRTT EEAPSAPPQ SVTVLTVGS 
YNSTSISVS WDPPPPDHQ NGIIQEYKI 
WCLGNETRF HINKTVDAA IRSVIIGGL 
FPGIQYRVE VAASTSAGV GVKSEPQPI 
IIGRRNEVV ITENNNSIT EQITDVVKQ 
PAFIAGIGG ACWVILMGF SIWLYWRRK 
KRKGLSNYA VTFQRGDGG LMSNGSRPG 
LLNAGDPSY PWLADSWPA TSLPVNNSN 
SGPNEIGNF GRGDVLPPV PGQGDKTAT 
MLSDGAIYS SIDFTTKTS YNSSSQITQ 
ATPYATTQI LHSNSIHEL AVDLPDPQW 
KSSIQQKTD LMGFGYSLP DQNKGNNGG 
KGGKKKKNK NSSKPQKNN GSTWANVPL 
PPPPVQPLP GTELEHYAV EQQENGYDS 
DSWCPPLPV QTYLHQGLE DELEEDDDR 
VPTPPVRGV ASSPAISFG QQSTATLTP 
SPREEMQPM LQAHLDELT RAYQFDIAK 
QTWHIQSNN QPPQPPVPP LGYVSGALI 
SDLETDVAD DDADDEEEA LEIPRPLRA 
LDQTPGSSM DNLDSSVTG KAFTSSQRP 
RPTSPFSTD SNTSAALSQ SQRPRPTKK 
HKGGRMDQQ PALPHRREG MTDEEALVP 
YSKPSFPSP GGHSSSGTA SSKGSTGPR 
KTEVLRAGH QRNASDLLD IGYMGSNSQ 
GQFTGEL
UniProt Q9HCK4

Binding hormones

  • slit-2 isoform 1 C-product

Anatomical structures with this receptor

  • brain

  • ovary

  • spinal_cord

Reference