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Details for receptor: FPRL1

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EndoNet ID: ENR01216

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Synonyms

  • LXA4R
  • LXA4 receptor
  • lipoxin A4 receptor
  • FMLP-related receptor I
  • FMLP-R-I
  • formyl peptide receptor-like 1
  • RFP
  • HM63
  • FPRL1
  • FPR2
  • FPRH1

General information

Links to other resources

UniProt P25090
Ensembl ENST00000340023

Subunit information

Sequence 
METNFSTPL NEYEEVSYE SAGYTVLRI 
LPLVVLGVT FVLGVLGNG LVIWVAGFR 
MTRTVTTIC YLNLALADF SFTATLPFL 
IVSMAMGEK WPFGWFLCK LIHIVVDIN 
LFGSVFLIG FIALDRCIC VLHPVWAQN 
HRTVSLAMK VIVGPWILA LVLTLPVFL 
FLTTVTIPN GDTYCTFNF ASWGGTPEE 
RLKVAITML TARGIIRFV IGFSLPMSI 
VAICYGLIA AKIHKKGMI KSSRPLRVL 
TAVVASFFI CWFPFQLVA LLGTVWLKE 
MLFYGKYKI IDILVNPTS SLAFFNSCL 
NPMLYVFVG QDFRERLIH SLPTSLERA 
LSEDSAPTN DTAANSASP PAETELQAM

Binding hormones

  • abeta42
    • Humanin and Aβ42 both activated FPRL1; however, only Aβ42 caused apoptotic death of the cells. [1]
  • humanin
    • Humanin and Aβ42 both activated FPRL1; however, only Aβ42 caused apoptotic death of the cells. [1]
  • LXA4
  • annexin A1
    • AnxA1 has been shown to stimulate FPRL-1. [2]

Anatomical structures with this receptor

  • neutrophil_granulocyte

  • lung

  • monocyte

    Induced phenotypes

    • monocyte activation
      • Recently, we found that a G-protein-coupled, seven-transmembrane receptor, FPRL1, mediates the migration and activation of monocytes and microglia induced by Aβ42. [3]
    • FPRL1 is expressed in a great variety of cells including monocytes. [4]
Reference