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Details for receptor: GLT1

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  • General information
  • Subunits
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  • Hormones
  • Anatomical structures
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EndoNet ID: ENR01222

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • glutamate/aspartate transporter II
  • SLC1A2
  • GLT1
  • EAAT2
  • excitatory amino acid transporter 2
  • solute carrier family 1 member 2
  • GLT-1
  • sodium-dependent glutamate/aspartate transporter 2

General information

  • GLT1 is severely down-regulated in amyotrophic lateral sclerosis, a progressive neurodegenerative disease. [1]
  • Pure astroglial cultures expressed only GLAST, whereas astrocytes grown in the presence of neurons expressed both GLAST (at increased levels) and GLT1 [1]

Links to other resources

UniProt P43004
Ensembl ENST00000449068

Subunit information

Subunit (3 times)

Sequence 
MASTEGANN MPKQVEVRM HDSHLGSEE 
PKHRHLGLR LCDKLGKNL LLTLTVFGV 
ILGAVCGGL LRLASPIHP DVVMLIAFP 
GDILMRMLK MLILPLIIS SLITGLSGL 
DAKASGRLG TRAMVYYMS TTIIAAVLG 
VILVLAIHP GNPKLKKQL GPGKKNDEV 
SSLDAFLDL IRNLFPENL VQACFQQIQ 
TVTKKVLVA PPPDEEANA TSAVVSLLN 
ETVTEVPEE TKMVIKKGL EFKDGMNVL 
GLIGFFIAF GIAMGKMGD QAKLMVDFF 
NILNEIVMK LVIMIMWYS PLGIACLIC 
GKIIAIKDL EVVARQLGM YMVTVIIGL 
IIHGGIFLP LIYFVVTRK NPFSFFAGI 
FQAWITALG TASSAGTLP VTFRCLEEN 
LGIDKRVTR FVLPVGATI NMDGTALYE 
AVAAIFIAQ MNGVVLDGG QIVTVSLTA 
TLASVGAAS IPSAGLVTM LLILTAVGL 
PTEDISLLV AVDWLLDRM RTSVNVVGD 
SFGAGIVYH LSKSELDTI DSQHRVHED 
IEMTKTQSI YDDMKNHRE SNSNQCVYA 
AHNSVIVDE CKVTLAANG KSADCSVEE 
EPWKREK

Binding hormones

  • L-glutamate
  • D-aspartate
  • L-aspartate

Anatomical structures with this receptor

  • astrocyte

    Induced phenotypes

    • termination of excitatory nerve signals
      • The astrocyte glutamate transporter GLT1 is responsible for significant portions of glutamate transport from the synaptic cleft, therby regulating synaptic transmission and preventing exitotoxicity. [2]
    • motor neuron loss
      • The glutamate transporter GLT1 triggers motor neuron loss in mutant SOD1-mediated diseases, pointing at the fact that GLT1 plays a role in disease propagation rather than initiation. [2]
Reference