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Details for receptor: Transient receptor potential cation channel subfamily V member 1

EndoNet ID: ENR01237

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Synonyms

  • Vanilloid receptor 1
  • Capsaicin receptor
  • VR1
  • Transient receptor potential cation channel subfamily V member 1
  • Osm-9-like TRP channel 1
  • OTRPC1
  • TrpV1

General information

  • VR1 is thought to be an integrator of painful stimuli since it can be synergistically activated by capsaicin, low pH, and heat. [1]
  • Capsazepine exhibited a concentration-dependent inhibition of capsaicin-induced currents in hVR1 expressing oocytes [1]

Links to other resources

UniProt Q8NER1
Ensembl ENST00000425167

Subunit information

Sequence
MKKWSSTDL GAAADPLQK DTCPDPLDG 
DPNSRPPPA KPQLSTAKS RTRLFGKGD 
SEEAFPVDC PHEEGELDS CPTITVSPV 
ITIQRPGDG PTGARLLSQ DSVAASTEK 
TLRLYDRRS IFEAVAQNN CQDLESLLL 
FLQKSKKHL TDNEFKDPE TGKTCLLKA 
MLNLHDGQN TTIPLLLEI ARQTDSLKE 
LVNASYTDS YYKGQTALH IAIERRNMA 
LVTLLVENG ADVQAAAHG DFFKKTKGR 
PGFYFGELP LSLAACTNQ LGIVKFLLQ 
NSWQTADIS ARDSVGNTV LHALVEVAD 
NTADNTKFV TSMYNEILI LGAKLHPTL 
KLEELTNKK GMTPLALAA GTGKIGVLA 
YILQREIQE PECRHLSRK FTEWAYGPV 
HSSLYDLSC IDTCEKNSV LEVIAYSSS 
ETPNRHDML LVEPLNRLL QDKWDRFVK 
RIFYFNFLV YCLYMIIFT MAAYYRPVD 
GLPPFKMEK TGDYFRVTG EILSVLGGV 
YFFFRGIQY FLQRRPSMK TLFVDSYSE 
MLFFLQSLF MLATVVLYF SHLKEYVAS 
MVFSLALGW TNMLYYTRG FQQMGIYAV 
MIEKMILRD LCRFMFVYI VFLFGFSTA 
VVTLIEDGK NDSLPSEST SHRWRGPAC 
RPPDSSYNS LYSTCLELF KFTIGMGDL 
EFTENYDFK AVFIILLLA YVILTYILL 
LNMLIALMG ETVNKIAQE SKNIWKLQR 
AITILDTEK SFLKCMRKA FRSGKLLQV 
GYTPDGKDD YRWCFRVDE VNWTTWNTN 
VGIINEDPG NCEGVKRTL SFSLRSSRV 
SGRHWKNFA LVPLLREAS ARDRQSAQP 
EEVYLRQFS GSLKPEDAE VFKSPAASG 
EK

Binding hormones

  • NGF
    • NGF-induced bladder overactivity and noxious input depend on the interaction of NGF with TRPV1 [2]
  • Calmodulin

Anatomical structures with this receptor

  • dorsal_root_ganglion

    Induced phenotypes

    • sensory perception of pain
      • VR1 is essential for the development of sensitization to thermal stimuli during inflammation but not for the normal sensation of noxious heat. [3]
  • mast_cell

    Induced phenotypes

    • Pruritus
      • Vanilloid receptor subtype 1 (VR1) is an important regulator of the cutaneous neuroimmune system. [4]
      • Direct activation of VR1 on mast cells may lead to the release of mast cell mediators which then are able to induce pruritus by binding to histamine- and proteinase-activated-2 (PAR-2) receptors on sensory nerve fibers. [4]
    • VR1 expression was observed on dermal mast cells and mast cell line HMC1 both at the protein and at the mRNA levels. [4]
  • spinal_cord

    Induced phenotypes

    • sensory perception of pain
      • VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia. [5]
      • Inflammatory mediators augment nociceptor thermal responsiveness, in part, through their actions on VR1. [5]
  • urinary_bladder

    Induced phenotypes

    • detection of mechanical stimulus
      • VR1 has a role in normal bladder function and sensing of bladder distension, particularly via the detection of mechanical stimuli by the urothelium. [6]
    • bladder activity
      • NGF-induced bladder overactivity and noxious input depend on the interaction of NGF with TRPV1. [2]
      • TRPV1 is essential for NGF-driven bladder dysfunction and represents a bottleneck target in bladder pathologies associated with NGF up-regulation. [2]
    • n overactive bladder syndrome and interstitial cystitis/bladder pain syndrome TRPV1 overexpression has been described in the bladder wall, both in urothelial cells and in suburothelial nerve fibres [2]
Reference