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Details for receptor: IL-28R-alpha-v1

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EndoNet ID: ENR01247

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Synonyms

  • IL-28R-alpha-v1
  • IL-28 receptor alpha
  • IL-28RA
  • Cytokine receptor class-II member 12
  • Cytokine receptor family 2 member 12
  • CRF2-12
  • Interferon lambda receptor 1
  • IFN-lambda R1
  • cytokine receptor 2

General information

  • The class II cytokine receptor IL-28Rα mediates the antiviral activity of IL-28 and IL-29. [1]

Links to other resources

UniProt Q8IU57-1
Ensembl ENST00000428464

Subunit information

Isoform 1

  • IL-28 and IL-29 signal through a heterodimeric class II cytokine receptor that consists of IL-28Rα and IL-10Rβ. [1]
Sequence 
RPRLAPPQN VTLLSQNFS VYLTWLPGL 
GNPQDVTYF VAYQSSPTR RRWREVEEC 
AGTKELLCS MMCLKKQDL YNKFKGRVR 
TVSPSSKSP WVESEYLDY LFEVEPAPP 
VLVLTQTEE ILSANATYQ LPPCMPPLD 
LKYEVAFWK EGAGNKTLF PVTPHGQPV 
QITLQPAAS EHHCLSART IYTFSVPKY 
SKFSKPTCF LLEVPEANW AFLVLPSLL 
ILLLVIAAG GVIWKTLMG NPWFQRAKM 
PRALDFSGH THPVATFQP SRPESVNDL 
FLCPQKELT RGVRPTPRV RAPATQQTR 
WKKDLAEDE EEEDEEDTE DGVSFQPYI 
EPPSFLGQE HQAPGHSEA GGVDSGRPR 
APLVPSEGS SAWDSSDRS WASTVDSSW 
DRAGSSGYL AEKGPGQGP GGDGHQESL 
PPPEFSKDS GFLEELPED NLSSWATWG 
TLPPEPNLV PGGPPVSLQ TLTFCWESS 
PEEEEEARE SEIEDSDAG SWGAESTQR 
TEDRGRTLG HYMAR

Binding hormones

  • IL-28B
  • IL-29
  • IL-28A
    • IL-28 signal through a heterodimeric class II cytokine receptor that consists of IL-28Rα and IL-10Rβ. [1]

Anatomical structures with this receptor

  • heart

  • skeleton_muscle

  • thyroid_gland

  • testis

  • prostate

  • pancreas

Reference