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Details for receptor: Lysophosphatidic acid receptor 3

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EndoNet ID: ENR01265

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Synonyms

  • LPA receptor 3
  • LPAR3
  • Lysophosphatidic acid receptor Edg-7
  • Lysophosphatidic acid receptor 3
  • edg7

General information

  • Belongs to the G-protein coupled receptor 1 family.
  • Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
  • LPA3 shows a marked preference for ligands with an sn-2 unsaturated fatty-acid ester. [1]

Links to other resources

UniProt Q9UBY5
Ensembl ENST00000440886

Subunit information

Subunit (1 times)

Sequence 
MNECHYDKH MDFFYNRSN TDTVDDWTG 
TKLVIVLCV GTFFCLFIF FSNSLVIAA 
VIKNRKFHF PFYYLLANL AAADFFAGI 
AYVFLMFNT GPVSKTLTV NRWFLRQGL 
LDSSLTASL TNLLVIAVE RHMSIMRMR 
VHSNLTKKR VTLLILLVW AIAIFMGAV 
PTLGWNCLC NISACSSLA PIYSRSYLV 
FWTVSNLMA FLIMVVVYL RIYVYVKRK 
TNVLSPHTS GSISRRRTP MKLMKTVMT 
VLGAFVVCW TPGLVVLLL DGLNCRQCG 
VQHVKRWFL LLALLNSVV NPIIYSYKD 
EDMYGTMKK MICCFSQEN PERRPSRIP 
STVLSRSDT GSQYIEDSI SQGAVCNKS 
TS
UniProt Q9UBY5-1

Binding hormones

  • lysophosphatidic acid
    • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Anatomical structures with this receptor

  • hair_follicle

  • microvascularendothelial_cell

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Influences

    • positive C-C motif chemokine 2
    • positive IL-1 beta
    • positive IL-8

  • vascularendothelial_cell

    Induced phenotypes

    • negative regulation of apoptosis
      • S1P protects VECs from serum-deprived apoptosis by nitric oxide production through S1P3 receptor. [2]

  • prostate

  • testis

  • pancreas

  • heart

  • lung

  • ovary

    Induced phenotypes

    • Ovarian cancer
      • LPAR3 may play a role in the development of ovarian cancer. [3]
    • Ovarian cancer
      • LPA3, in addition to LPA2, was associated with increased OCC aggressiveness in vivo due to their contribution to the tumorigenic activity of LPA. [3]

  • kidney

  • brain

  • frontal_lobe

  • hippocampus

  • amygdaloid_body

  • microglial_cell_in_central_nervous_system

    Induced phenotypes

    • regulation of inflammatory response
      • It is notable that LPA3 is upregulated in lipopolysaccharide-stimulated microglia, suggesting a role for LPA signaling in activated microglia during neuroinflammation. [4]

  • oligodendrocyte

  • platelet

    Induced phenotypes

    • atherosclerosis
      • LPA has been implicated in the development of atherosclerosis during early (barrier dysfunction and monocyte adhesion of the endothelium) and later phases (platelet activation and thrombosis). [5]
      • LPA was found to accumulate in the thrombogenic lipid-rich core of atherosclerotic plaques. Pharmacological studies identified LPA3 as primary mediator of LPA-induced platelet activation. [6]
      • The effect of LPA on platelets may be species-specific, because LPA was found to inhibit platelet activation in mice. [7]

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • LPA3 activation induced chemotaxis of immature, but not mature, DCs. [8]

  • uterus

    Induced phenotypes

    • embryo implantation
      • The most significant role of LPA signaling in reproductive function involves that of LPA3-mediated embryo implantation into the uterine wall. LPA3-deficient female mice showed delayed implantation, embryo crowding, and reduced litter size. [9]

  • neuron

    Induced phenotypes

    • neuron projection morphogenesis
      • Overexpression of LPA3 in neuroblastoma cells leads to neurite elongation. [10]

  • small_intestine

Reference