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Details for receptor: Lysophosphatidic acid receptor 6

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EndoNet ID: ENR01296

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Synonyms

  • Oleoyl-L-alpha-lysophosphatidic acid receptor
  • P2Y purinoceptor 5
  • Lysophosphatidic acid receptor 6
  • LPA receptor 6
  • P2Y5
  • LPA6
  • LPAR6

General information

  • In the receptor activation is intracellular cAMP involved. [1]
  • The receptor is involved in human hair growth [1]
  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt P43657
Ensembl ENST00000435430

Subunit information

Subunit (1 times)

Sequence 
MVSVNSSHC FYNDSFKYT LYGCMFSMV 
FVLGLISNC VAIYIFICV LKVRNETTT 
YMINLAMSD LLFVFTLPF RIFYFTTRN 
WPFGDLLCK ISVMLFYTN MYGSILFLT 
CISVDRFLA IVYPFKSKT LRTKRNAKI 
VCTGVWLTV IGGSAPAVF VQSTHSQGN 
NASEACFEN FPEATWKTY LSRIVIFIE 
IVGFFIPLI LNVTCSSMV LKTLTKPVT 
LSRSKINKT KVLKMIFVH LIIFCFCFV 
PYNINLILY SLVRTQTFV NCSVVAAVR 
TMYPITLCI AVSNCCFDP IVYYFTSDT 
IQNSIKMKN WSVRRSDFR FSEVHGAEN 
FIQHNLQTL KSKIFDNES AA
UniProt P43657-1

Binding hormones

  • lysophosphatidic acid
    • Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation.

Anatomical structures with this receptor

  • skin

  • hair_follicle

    Induced phenotypes

    • autosomal recessive woolly hair
      • P2Y5 was identified as a critical mediator for human hair growth and is a causal gene of a rare familial form of human hair loss. [2]

  • peripheral blood leukocytes

Reference