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Details for receptor: GPR44

EndoNet ID: ENR01302

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  • GPR44
  • DP2
  • G protein-coupled receptor 44
  • CRTH2

General information

  • seven-transmembrane G protein–coupled receptor [1]
  • preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils [2]
  • induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells [1]
  • mediates PGD2-dependent cell migration of blood eosinophils and basophils (different to DP) [1]
  • likely involved in multiple aspects of allergic inflammation [1]
  • agonist is prostaglandin PGD2 [1]
  • CRTH2 is coupled with G alpha i-type G protein [1]

Links to other resources

Binding hormones

  • PGD2

Anatomical structures with this receptor