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Details for receptor: free fatty acid receptor 1

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EndoNet ID: ENR01315

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Synonyms

  • free fatty acid receptor 1
  • G protein coupled receptor 40
  • FFAR1
  • GPR40

General information

  • Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. [1]

Links to other resources

UniProt O14842
Ensembl ENST00000246553

Subunit information

Sequence 
MDLPPQLSF GLYVAAFAL GFPLNVLAI 
RGATAHARL RLTPSLVYA LNLGCSDLL 
LTVSLPLKA VEALASGAW PLPASLCPV 
FAVAHFFPL YAGGGFLAA LSAGRYLGA 
AFPLGYQAF RRPCYSWGV CAAIWALVL 
CHLGLVFGL EAPGGWLDH SNTSLGINT 
PVNGSPVCL EAWDPASAG PARFSLSLL 
LFFLPLAIT AFCYVGCLR ALARSGLTH 
RRKLRAAWV AGGALLTLL LCVGPYNAS 
NVASFLYPN LGGSWRKLG LITGAWSVV 
LNPLVTGYL GRGPGLKTV CAARTQGGK 
SQK
UniProt O14842-1

Binding hormones

  • free fatty acid

Anatomical structures with this receptor

  • beta_cell_of_islet_of_Langerhans

    Influences

    • negative insulin
      • Recent studies documented that free fatty acid receptor 1 (GPR40) mediates both acute stimulatory and chronic inhibitory effects of FFAs on insulin secretion and that GPR40 signaling is linked to impaired glucose homeostasis. [2]
    • positive insulin
      • Recent studies documented that free fatty acid receptor 1 (GPR40) mediates both acute stimulatory and chronic inhibitory effects of FFAs on insulin secretion and that GPR40 signaling is linked to impaired glucose homeostasis. [2]
Reference