Status
Please wait ...

Details for receptor: Sphingosine 1-phosphate receptor 5

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01320

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • Sphingosine 1-phosphate receptor Edg-8
  • Sphingosine 1-phosphate receptor 5
  • S1PR5
  • edg8
  • Endothelial differentiation G-protein-coupled receptor 8

General information

  • Belongs to the G-protein coupled receptor 1 family.
  • Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins.
  • There are two isoforms produced by alternative splicing.

Links to other resources

UniProt Q9H228
Ensembl ENST00000333430

Subunit information

isoform 1 (1 times)

  • There are two isoforms produced by alternative splicing.
Sequence 
MESGLLRPA PVSEVIVLH YNYTGKLRG 
ARYQPGAGL RADAVVCLA VCAFIVLEN 
LAVLLVLGR HPRFHAPMF LLLGSLTLS 
DLLAGAAYA ANILLSGPL TLKLSPALW 
FAREGGVFV ALTASVLSL LAIALERSL 
TMARRGPAP VSSRGRTLA MAAAAWGVS 
LLLGLLPAL GWNCLGRLD ACSTVLPLY 
AKAYVLFCV LAFVGILAA ICALYARIY 
CQVRANARR LPARPGTAG TTSTRARRK 
PRSLALLRT LSVVLLAFV ACWGPLFLL 
LLLDVACPA RTCPVLLQA DPFLGLAMA 
NSLLNPIIY TLTNRDLRH ALLRLVCCG 
RHSCGRDPS GSQQSASAA EASGGLRRC 
LPPGLDGSF SGSERSSPQ RDGLDTSGS 
TGSPGAPTA ARTLVSEPA AD
UniProt Q9H228-1

isoform 2 (1 times)

  • There are two isoforms produced by alternative splicing.
Sequence 
MESGLLRPA PVSEVIVLH YNYTGKLRG 
ARYQPGAGL RADAVVCLA VCAFIVLEN 
LAVLLVLGR HPRFHAPMF LLLGSLTLS 
DLLAGAAYA ANILLSGPL TLKLSPALW 
FAREGGVFV ALTASVLSL LAIALERSL 
TMARRGPAP VSSRGRTLA MAAAAWGVS 
LLLGLLPAL GWNCLGRLD ACSTVLPLY 
AKAYVLFCV LAFVGILAA ICALYALAG 
LAAHAQRGA PGLCGMLGP PHPAAVARR 
GVPGAHLSC TPAGRSLPG TGHGQLTSE 
PHHLHAHQP RPAPRAPAP GLLRTPLLR 
QRPEWLPAV GERG
UniProt Q9H228-2

Binding hormones

  • sphingosine 1-phosphate
    • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P).
  • Sphingosylphosphorylcholine
    • All of the subsequently identified S1P receptors of the EDG family exhibited a low affinity for SPC and might thus rather mediate some of SPC's extracellular actions in the low micromolar concentration range. [1]

Anatomical structures with this receptor

  • oligodendrocyte

    Induced phenotypes

    • regulation of myelination
      • S1P5 expressed by oligodendrocytes might play a role in normal myelination and in demyelinating diseases, such as multiple sclerosis, as its expression is restricted to oligodendrocytes throughout development from immature stages to myelin-forming cells. [2]

  • brain

    Induced phenotypes

    • proliferation of radial glia cells
      • S1PR5 may play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. [3]
    • astrocyte development
      • S1PR5 is the receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. S1PR5 may play a regulatory role in the transformation of radial glial cells into astrocytes [3]

  • corpus_callosum

  • white_matter

    Induced phenotypes

    • regulation of oligodendrocyte differentiation
      • In the brain, S1P5 is predominantly expressed in white matter tracts and cells of oligodendrocyte lineage, suggesting its potential roles in maturation and myelination of oligodendrocytes. [4]

  • spleen

  • peripheral blood leukocytes

  • placenta

  • lung

  • aorta

    Induced phenotypes

    • positive regulation of angiogenesis
      • S1P promotes endothelial cell growth, thereby promoting blood vessel formation through the interacction with signaling by VEGF. [5]

  • lymphocyte

    Induced phenotypes

    • LGL leukemia
      • Human sphingosine-1-phosphate receptor 5 gene (S1P5) is overexpressed in large granular lymphocyte (LGL) leukemia. [6]
      • LGL is a lymphopropliferative disorder often associated with autoimmune disease. [6]

  • immune_system

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • FTY720, a S1P receptor agonist, can severly hamper migration of dendritic cells to the lymph nodes suggesting additional mechanisms underlying the immunosuppressive effects of this spingosine analog. [7]

  • killer_cell

    Induced phenotypes

    • positive regulation of leukocyte migration
      • NK cells rely on S1PR5 to attain a normal tissue distribution, which might also function to promote egress from the bone marrow and lymph nodes into the vascular compartments in response to S1P gradients. [8]

  • osteoblast

  • skin

  • keratinocyte

Reference