Status
Please wait ...

Details for receptor: G-protein coupled receptor 12

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01322

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • GPR12
  • GPCR01
  • G-protein coupled receptor 12

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt P47775
Ensembl ENST00000405846

Subunit information

Subunit (1 times)

Sequence 
MNEDLKVNL SGLPRDYLD AAAAENISA 
AVSSRVPAV EPEPELVVN PWDIVLCTS 
GTLISCENA IVVLIIFHN PSLRAPMFL 
LIGSLALAD LLAGIGLIT NFVFAYLLQ 
SEATKLVTI GLIVASFSA SVCSLLAIT 
VDRYLSLYY ALTYHSERT VTFTYVMLV 
MLWGTSICL GLLPVMGWN CLRDESTCS 
VVRPLTKNN AAILSVSFL FMFALMLQL 
YIQICKIVM RHAHQIALQ HHFLATSHY 
VTTRKGVST LAIILGTFA ACWMPFTLY 
SLIADYTYP SIYTYATLL PATYNSIIN 
PVIYAFRNQ EIQKALCLI CCGCIPSSL 
AQRARSPSD V
UniProt P47775-1

Binding hormones

  • sphingosine 1-phosphate
    • Was originally thought to be a receptor for sphingosine 1-phosphate. [1]
    • It has been demonstrated that it is not the case in human. [2]
  • Sphingosylphosphorylcholine

Anatomical structures with this receptor

  • brain

    Induced phenotypes

    • positive regulation of neuron differentiation
      • SPC stimulates cell proliferation and clustering in hippocampal HT22 cell lines, and it increases amounts of synaptophysin (a neuronal differentiation marker) in primary rat cortical cells that could be mediated by GPR12, suggesting roles for SPC–GPR12 signaling in neuronal differentiation. [3]

  • testis

  • liver

Reference