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Details for receptor: Ovarian cancer G-protein coupled receptor 1

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EndoNet ID: ENR01324

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Synonyms

  • Ovarian cancer G-protein coupled receptor 1
  • OGR1
  • G-protein coupled receptor 68
  • Sphingosylphosphorylcholine receptor
  • GPR12A

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt Q15743
Ensembl ENST00000238699

Subunit information

Subunit (1 times)

Sequence 
MGNITADNS SMSCTIDHT IHQTLAPVV 
YVTVLVVGF PANCLSLYF GYLQIKARN 
ELGVYLCNL TVADLFYIC SLPFWLQYV 
LQHDNWSHG DLSCQVCGI LLYENIYIS 
VGFLCCISV DRYLAVAHP FRFHQFRTL 
KAAVGVSVV IWAKELLTS IYFLMHEEV 
IEDENQHRV CFEHYPIQA WQRAINYYR 
FLVGFLFPI CLLLASYQG ILRAVRRSH 
GTQKSRKDQ IQRLVLSTV VIFLACFLP 
YHVLLLVRS VWEASCDFA KGVFNAYHF 
SLLLTSFNC VADPVLYCF VSETTHRDL 
ARLRGACLA FLTCSRTGR AREAYPLGA 
PEASGKSGA QGEEPELLT KLHPAFQTP 
NSPGSGGFP TGRLA
UniProt Q15743-1

Binding hormones

  • Sphingosylphosphorylcholine
    • Was originally thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted. [1]

Anatomical structures with this receptor

  • lung

  • kidney

  • bone

  • placenta

  • brain

    Induced phenotypes

    • positive regulation of neuron projection development
      • OGR1 is expressed in the brain. SPC induced a neurite outgrowth in the different neuroblastoma cell lines. [2]

  • heart

  • spleen

  • testis

  • small_intestine

  • peripheral blood lymphocytes

  • immune_system

Reference