Status
Please wait ...

Details for receptor: G-protein coupled receptor 4

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01325

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • G-protein coupled receptor 4
  • G-protein coupled receptor 19
  • GPR4
  • GPR19

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt P46093
Ensembl ENST00000323040

Subunit information

Subunit (1 times)

Sequence 
MGNHTWEGC HVDSRVDHL FPPSLYIFV 
IGVGLPTNC LALWAAYRQ VQQRNELGV 
YLMNLSIAD LLYICTLPL WVDYFLHHD 
NWIHGPGSC KLFGFIFYT NIYISIAFL 
CCISVDRYL AVAHPLRFA RLRRVKTAV 
AVSSVVWAT ELGANSAPL FHDELFRDR 
YNHTFCFEK FPMEGWVAW MNLYRVFVG 
FLFPWALML LSYRGILRA VRGSVSTER 
QEKAKIKRL ALSLIAIVL VCFAPYHVL 
LLSRSAIYL GRPWDCGFE ERVFSAYHS 
SLAFTSLNC VADPILYCL VNEGARSDV 
AKALHNLLR FLASDKPQE MANASLTLE 
TPLTSKRNS TAKAMTGSW AATPPSQGD 
QVQLKMLPP AQ
UniProt P46093-1

Binding hormones

  • Sphingosylphosphorylcholine
    • High-affinity receptor for SPC. [1]
  • lysophosphatidylcholine
    • Low-affinity receptor for LPC [1]

Anatomical structures with this receptor

  • ovary

  • liver

  • lung

  • kidney

  • heart

  • lymph_node

  • macrophage

    Induced phenotypes

    • atherosclerosis
      • The key role of LPC as a major antigenic component of oxLDL has implicated this bioactive lipid in atherosclerosis, the primary cause of heart disease and stroke. [2]
      • Aspects of immune function as potential targets of LPC action play some role in atherogenesis. Macrophage responses to oxLDL such as migration and activation are likely determined to a significant extent by its LPC content, and may therefore be mediated to some degree via G2A and/or GPR4. [2]

  • brain

  • immune_system

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Induced phenotypes

    • positive regulation of cell growth
      • A strong mitogenic effect of SPC was observed in a large number of cell types, such as endothelial cells from different vascular beds. [3]
      • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [4]

  • keratinocyte

    Induced phenotypes

    • positive regulation of cell growth
      • A strong mitogenic effect of SPC was observed in a large number of cell types, such as human keratinocytes. [5]
      • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [4]

  • smooth_muscle_cell

    Induced phenotypes

    • positive regulation of cell growth
      • A strong mitogenic effect of SPC was observed in a large number of cell types, such as vascular smooth muscle cells. [6]
      • Of the high-affinity SPC-GPCRs identified so far, GPR4 mediated stimulation of cell growth. [7]
Reference