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Details for receptor: Psychosine receptor

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EndoNet ID: ENR01327

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Synonyms

  • T-cell death-associated gene 8 protein
  • Psychosine receptor
  • G-protein coupled receptor 65
  • GPR65
  • TDAG8

General information

  • Belongs to the G-protein coupled receptor 1 family.

Links to other resources

UniProt Q8IYL9
Ensembl ENST00000267549

Subunit information

Subunit (1 times)

Sequence 
MNSTCIEEQ HDLDHYLFP IVYIFVIIV 
SIPANIGSL CVSFLQAKK ESELGIYLF 
SLSLSDLLY ALTLPLWID YTWNKDNWT 
FSPALCKGS AFLMYMNFY SSTAFLTCI 
AVDRYLAVV YPLKFFFLR TRRFALMVS 
LSIWILETI FNAVMLWED ETVVEYCDA 
EKSNFTLCY DKYPLEKWQ INLNLFRTC 
TGYAIPLVT ILICNRKVY QAVRHNKAT 
ENKEKKRII KLLVSITVT FVLCFTPFH 
VMLLIRCIL EHAVNFEDH SNSGKRTYT 
MYRITVALT SLNCVADPI LYCFVTETG 
RYDMWNILK FCTGRCNTS QRQRKRILS 
VSTKDTMEL EVLE
UniProt Q8IYL9-1

Binding hormones

    Anatomical structures with this receptor

    • immune_system

    • placenta

    • lung

    • thymus

    • spleen

    • lymph_node

    • small_intestine

    • peripheral blood leukocytes

    • brain

      Induced phenotypes

      • Krabbe disease
        • Globoid cell leukodystrophy (GLD; also known as Krabbe's disease) is a hereditary metabolic disorder of infants, characterized morphologically by almost total absence of myelin, severe gliosis, and the presence of characteristic, multinucleated globoid cells in the white matter. [1]
        • The deficiency of the catabolic enzyme galatosyl ceramidase results in accumulation of psychosine (PSY; d-galactosyl-β-1,1′-sphingosine) in the brain. [1]
        • This accumulation of PSY in the white matter of children with GLD correlates temporally with apoptosis of oligodendrocytes and globoid cell formation by microglia. [2]
        • The PSY/TDAG8 pair evokes a multinuclear phenotype in cultured cells reminiscent of the globoid cell formation that is the neurohistoligic fingerprint of Krabbe's disease. [3]
      • negative regulation of cytokinesis
        • Psy inhibits cytokinesis and induces the formation of multinuclear globular giant cells. Psy-induced formation of multinuclear cells was not due to cell–cell fusion but to inhibition of cytokinesis. [4]

    • white_matter

    • T-lymphocyte

      Induced phenotypes

      • positive regulation of activation-induced cell death of T cells
        • The tissue-specific expression of TDAG8 and the induction of its expression during cell death of T cells mediated by the TCR or glucocorticoids suggest that it may have a role in activation-induced cell death of T cells. [5]
      • positive regulation of T cell differentiation in the thymus
        • The tissue-specific expression of TDAG8 and the induction of its expression during cell death of T cells mediated by the TCR or glucocorticoids suggest that it may have a role in activation-induced differentiation of T cells. [5]

    • platelet

      Induced phenotypes

      • negative regulation of protein kinase activity
        • Lysosphingolipids potently and reversibly inhibited protein kinase C activity and binding of phorbol dibutyrate in vitro and in human platelets. [6]

    • liver

      Induced phenotypes

      • negative regulation of oxidoreductase activity
        • Galactosylsphingosine, glucosylsphingosine and sphingosine all inhibited cytochrome c oxidase activity in mitochondria from rat liver. [7]

    • oligodendrocyte

      Induced phenotypes

      • positive regulation of glial cell apoptosis
        • Psy is primarily accumulated in oligodendroglia, which contain abundant GalCer, a precursor of Psy. The accumulated Psy is cytotoxic, and these cells were therefore injured or died on Psy accumulation, probably due to apoptosis. [8]

    • microglial_cell_in_central_nervous_system

      Induced phenotypes

      • Krabbe disease
        • The secondary accumulation of Psy in microglia probably induces the formation of globoid cells. [4]

    • macrophage

      Induced phenotypes

      • Krabbe disease
        • The secondary accumulation of Psy in macrophages probably induces the formation of globoid cells. [4]
    Reference