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Details for receptor: FTS receptor

EndoNet ID: ENR01328

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  • FTS receptor
  • thymulin receptor
  • serum thymic factor receptor

General information

Links to other resources

Binding hormones

    Anatomical structures with this receptor

    • T-lymphocyte

      Induced phenotypes

      • positive regulation of T cell differentiation
        • Thymulin shows a large variety of effects on T cell functions, especially on T cell maturation. [1]
      • regulation of gene expression
        • In vivo thymulin treatment has effect on the IL-2R expression and on the avian CD4+ and CD8+ T cell populations. [2]
    • peripheral blood lymphocytes

      Induced phenotypes

      • anorexia nervosa
        • Thymulin activity was significantly reduced in the anorexia nervosa patients compared to sex- and age-matched healthy control subjects. The distribution of their peripheral lymphocyte cells into several subsets was not affected. [3]
        • The observed decrease of thymulin activity in this illness might be the consequence of thymic atrophy secondary to malnutrition and/or hormonal disturbances. [3]
    • pituitary_gland_of_diencephalon


      • positive ACTH
        • Thymulin modulates the secretion of ACTH by the anterior pituitary gland and that its actions are associated with increased cyclic nucleotide formation. [4]
      • negative PRL
        • Thymulin appears to exert an inhibitory influence on immunoreactive-PRL release. [4]
      • positive LH
        • Thymulin modulates possibly the secretion of LH by the anterior pituitary gland and that its actions are associated with increased cyclic nucleotide formation. [4]

      Induced phenotypes

      • gonadotropin hormone-releasing hormone activity
        • In an in vitro study using pituitary cells obtained from female rats in different days of the estrous cycle, it was observed that thymulin modulates the stimulatory activity of gonadotropin-releasing hormone on LH and follicle-stimulating hormone (FSH) release. [5]
      • neuroendocrine cell differentiation
        • Recent immunoneutralization studies have strengthened the hypothesis that thymulin is a physiological mediator of the perinatal influence of the thymus on neuroendocrine maturation. Thus, neonatal immunoneutralization of circulating thymulin in otherwise normal C57BL/6 mice induced significant morphologic alterations in most anterior pituitary endocrine cell populations when the animals reached puberty. [6]
        • Thymulin immunoneutralization from birth to puberty in normal mice also induced serum gonadotropin and serum TSH, PRL, and GH reduction when the animals reached puberty. [7]
      • regulation of steroid biosynthetic process
        • Thymulin also modulates gonadotropin-induced testicular steroidogenesis. [8]
        • There is in vitro and in vivo evidence suggesting that thymulin plays a role in the regulation of female spontaneous puberty, possibly through effects on pituitary gonadotropin release and ovarian steroidogenesis. [9]
    • thymic_epithelial_cell


      • negative Thymulin
        • Thymulin exerts a controlling feedback effect on its own secretion both in vivo and in vitro. Synthesis of this hormone can be down-regulated by the hormone itself. [10]
    • central_nerve_system_element

      Induced phenotypes

      • neuroprotection
        • The neuroprotective role of thymulin in the CNS becomes evident during inflammatory states. [11]
        • Thymulin appears to play a protective role against inflammation in the CNS. This protective effect appears to be exerted directly at the level of the CNS. [11]
      • regulation of sensory perception of pain
        • A series of experiments showing the hyperalgesic actions of thymulin in the nervous system. [11]
        • Thymulin may be acting directly or indirectly on nerve terminals of the CNS. PGE2 might be a key mediator in these actions. [11]
        • The attenuation of hyperalgesia by high doses of thymulin involve the downregulation of proinflammatory cytokines. [11]