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Details for receptor: steroidogenic factor 1

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EndoNet ID: ENR01334

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Synonyms

  • steroidogenic factor 1
  • Steroid hormone receptor Ad4BP
  • Nuclear receptor subfamily 5 group A member 1
  • Fushi tarazu factor homolog 1
  • Adrenal 4-binding protein
  • SF1

General information

  • orphan nuclear receptor [1]
  • phospholipid-binding was discovered in vitro but it remains to be seen if phospholipids or possibly other molecules regulate SF1 under physiological conditions [2]
  • in adrenocorticoid cells SF1 is bound to sphingosin (SH) and lyso-sphingomyelin (lysoSM) under basal conditions and cAMP stimulation decreases the amount of bound SPH and lysoSM bound to the receptor [3]
  • SF1 is a key regulator between hypothalamus-pituitary gonadal and adrenal axis [1]
  • essential nuclear receptor, constitutivy active [1]

Links to other resources

UniProt Q13285
Ensembl ENST00000373588

Subunit information

  • posttranscriptionally modified by acetylation, sumolyation and phosphorylation on Ser-203 by CDK-7 [1]
Sequence 
MDYSYDEDL DELCPVCGD KVSGYHYGL 
LTCESCKGF FKRTVQNNK HYTCTESQS 
CKIDKTQRK RCPFCRFQK CLTVGMRLE 
AVRADRMRG GRNKFGPMY KRDRALKQQ 
KKAQIRANG FKLETGPPM GVPPPPPPA 
PDYVLPPSL HGPEPKGLA AGPPAGPLG 
DFGAPALPM AVPGAHGPL AGYLYPAFP 
GRAIKSEYP EPYASPPQP GLPYGYPEP 
FSGGPNVPE LILQLLQLE PDEDQVRAR 
ILGCLQEPT KSRPDQPAA FGLLCRMAD 
QTFISIVDW ARRCMVFKE LEVADQMTL 
LQNCWSELL VFDHIYRQV QHGKEGSIL 
LVTGQEVEL TTVATQAGS LLHSLVLRA 
QELVLQLLA LQLDRQEFV CLKFIILFS 
LDLKFLNNH ILVKDAQEK ANAALLDYT 
LCHYPHCGD KFQQLLLCL VEVRALSMQ 
AKEYLYHKH LGNEMPRNN LLIEMLQAK 
QT
UniProt Q13285

Binding hormones

    Anatomical structures with this receptor

    • adrenal_gland

      Induced phenotypes

      • positive regulation of adrenal development

    • ovary

      • The presence of potential SF-l binding sites in the promoter regions of nonadrenal steroidogenic enzymes and the expression of SF-1 in ovary and testis suggested that SF-l might also contribute to steroidogenic enzyme gene expression in gonadal tissue [4]

    • testis

      • The presence of potential SF-l binding sites in the promoter regions of nonadrenal steroidogenic enzymes and the expression of SF-1 in ovary and testis suggested that SF-l might also contribute to steroidogenic enzyme gene expression in gonadal tissue [4]

    • hypothalamus

    • gonads

      Induced phenotypes

      • steroidogenesis
        • SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively [5]
      • The presence of potential SF-l binding sites in the promoter regions of nonadrenal steroidogenic enzymes and the expression of SF-1 in ovary and testis suggested that SF-l might also contribute to steroidogenic enzyme gene expression in gonadal tissue [4]
    Reference