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Details for receptor: IL-2R

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EndoNet ID: ENR01335

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Synonyms

  • IL-2R
  • Interleukin-2 receptor

General information

  • formation of the high-affinity quaternary IL-2-Il2R complex leads to signal transduction through the tyrosin kinases JAK1 and JAK3, which are associated with IL-2Rbeta and gammac, respectively [1]
  • IL-2R belongs to the gamma-chain family [1]

Links to other resources

Subunit information

Interleukin-2 receptor subunit alpha (3 times)

  • Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. [2]
  • IL-2 is firstcaptured by IL-2alpha through a large hydrophobic binding surface surrounded by a polar periphery [1]
Sequence 
MDSYLLMWG LLTFIMVPG CQAELCDDD 
PPEIPHATF KAMAYKEGT MLNCECKRG 
FRRIKSGSL YMLCTGNSS HSSWDNQCQ 
CTSSATRNT TKQVTPQPE EQKERKTTE 
MQSPMQPVD QASLPGHCR EPPPWENEA 
TERIYHFVV GQMVYYQCV QGYRALHRG 
PAESVCKMT HGKTRWTQP QLICTGEME 
TSQFPGEEK PQASPEGRP ESETSCLVT 
TTDFQIQTE MAATMETSI FTTEYQVAV 
AGCVFLLIS VLLLSGLTW QRRQRKSRR 
TI
UniProt P01589

Interleukin-2 receptor subunit beta (3 times)

Sequence 
MAAPALSWR LPLLILLLP LATSWASAA 
VNGTSQFTC FYNSRANIS CVWSQDGAL 
QDTSCQVHA WPDRRRWNQ TCELLPVSQ 
ASWACNLIL GAPDSQKLT TVDIVTLRV 
LCREGVRWR VMAIQDFKP FENLRLMAP 
ISLQVVHVE THRCNISWE ISQASHYFE 
RHLEFEART LSPGHTWEE APLLTLKQK 
QEWICLETL TPDTQYEFQ VRVKPLQGE 
FTTWSPWSQ PLAFRTKPA ALGKDTIPW 
LGHLLVGLS GAFGFIILV YLLINCRNT 
GPWLKKVLK CNTPDPSKF FSQLSSEHG 
GDVQKWLSS PFPSSSFSP GGLAPEISP 
LEVLERDKV TQLLLQQDK VPEPASLSS 
NHSLTSCFT NQGYFFFHL PDALEIEAC 
QVYFTYDPY SEEDPDEGV AGAPTGSSP 
QPLQPLSGE DDAYCTFPS RDDLLLFSP 
SLLGGPSPP STAPGGSGA GEERMPPSL 
QERVPRDWD PQPLGPPTP GVPDLVDFQ 
PPPELVLRE AGEEVPDAG PREGVSFPW 
SRPPGQGEF RALNARLPL NTDAYLSLQ 
ELQGQDPTH LV
UniProt P14784

Interleukin-2 receptor subunit gamma (3 times)

  • Common subunit of the receptors of a variety of interleukins, the gamma chain is commen to the IL2, IL4, IL7, IL21 and probably also the IL13 receptor [2]
Sequence 
MLKPSLPFT SLLFLQLPL LGVGLNTTI 
LTPNGNEDT TADFFLTTM PTDSLSVST 
LPLPEVQCF VFNVEYMNC TWNSSSEPQ 
PTNLTLHYW YKNSDNDKV QKCSHYLFS 
EEITSGCQL QKKEIHLYQ TFVVQLQDP 
REPRRQATQ MLKLQNLVI PWAPENLTL 
HKLSESQLE LNWNNRFLN HCLEHLVQY 
RTDWDHSWT EQSVDYRHK FSLPSVDGQ 
KRYTFRVRS RFNPLCGSA QHWSEWSHP 
IHWGSNTSK ENPFLFALE AVVISVGSM 
GLIISLLCV YFWLERTMP RIPTLKNLE 
DLVTEYHGN FSAWSGVSK GLAESLQPD 
YSERLCLVS EIPPKGGAL GEGPGASPC 
NQHSPYWAP PCYTLKPET
UniProt P31785

Binding hormones

    Anatomical structures with this receptor

    • B-lymphocyte

    • T-lymphocyte

      • Il-2 (...) binds to a high affinity receptor(..) found on Treg (regulatory T cell) cells and recently antigen-activated T-Lymphocytes [1]
    Reference