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Details for receptor: LFA-1

EndoNet ID: ENR01336

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Synonyms

  • Lymphocyte function-associated antigen 1
  • LFA-1
  • CD11a-CD18
  • alphaL-beta2

General information

  • LFA1 receptor is a heterodimer of Integrin alpha-L and Integrin beta-2 and is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 [1]
  • MeSH ID: D016169

Links to other resources

Subunit information

Integrin alpha-L

  • other names CD11a; LFA-1A; ITGAL [1]
Sequence
YNLDVRGAR SFSPPRAGR HFGYRVLQV 
GNGVIVGAP GEGNSTGSL YQCQSGTGH 
CLPVTLRGS NYTSKYLGM TLATDPTDG 
SILACDPGL SRTCDQNTY LSGLCYLFR 
QNLQGPMLQ GRPGFQECI KGNVDLVFL 
FDGSMSLQP DEFQKILDF MKDVMKKLS 
NTSYQFAAV QFSTSYKTE FDFSDYVKR 
KDPDALLKH VKHMLLLTN TFGAINYVA 
TEVFREELG ARPDATKVL IIITDGEAT 
DSGNIDAAK DIIRYIIGI GKHFQTKES 
QETLHKFAS KPASEFVKI LDTFEKLKD 
LFTELQKKI YVIEGTSKQ DLTSFNMEL 
SSSGISADL SRGHAVVGA VGAKDWAGG 
FLDLKADLQ DDTFIGNEP LTPEVRAGY 
LGYTVTWLP SRQKTSLLA SGAPRYQHM 
GRVLLFQEP QGGGHWSQV QTIHGTQIG 
SYFGGELCG VDVDQDGET ELLLIGAPL 
FYGEQRGGR VFIYQRRQL GFEEVSELQ 
GDPGYPLGR FGEAITALT DINGDGLVD 
VAVGAPLEE QGAVYIFNG RHGGLSPQP 
SQRIEGTQV LSGIQWFGR SIHGVKDLE 
GDGLADVAV GAESQMIVL SSRPVVDMV 
TLMSFSPAE IPVHEVECS YSTSNKMKE 
GVNITICFQ IKSLIPQFQ GRLVANLTY 
TLQLDGHRT RRRGLFPGG RHELRRNIA 
VTTSMSCTD FSFHFPVCV QDLISPINV 
SLNFSLWEE EGTPRDQRA QGKDIPPIL 
RPSLHSETW EIPFEKNCG EDKKCEANL 
RVSFSPARS RALRLTAFA SLSVELSLS 
NLEEDAYWV QLDLHFPPG LSFRKVEML 
KPHSQIPVS CEELPEESR LLSRALSCN 
VSSPIFKAG HSVALQMMF NTLVNSSWG 
DSVELHANV TCNNEDSDL LEDNSATTI 
IPILYPINI LIQDQEDST LYVSFTPKG 
PKIHQVKHM YQVRIQPSI HDHNIPTLE 
AVVGVPQPP SEGPITHQW SVQMEPPVP 
CHYEDLERL PDAAEPCLP GALFRCPVV 
FRQEILVQV IGTLELVGE IEASSMFSL 
CSSLSISFN SSKHFHLYG SNASLAQVV 
MKVDVVYEK QMLYLYVLS GIGGLLLLL 
LIFIVLYKV GFFKRNLKE KMEAGRGVP 
NGIPAEDSE QLASGQEAG DPGCLKPLH 
EKDSESGGG KD
UniProt P20701

Integrin beta-2

  • other names: CD18, MFI7; ITGB2 [1]
UniProt P05107

Binding hormones

  • ICAM-1
    • The discovery of ICAM-1 (CD54) as a ligand of the β2 integrin LFA-1 (αLβ2 or CD11a-CD18) established the receptor–ligand pair of a key adhesion pathway and revealed upregulation of ligand expression by inflammatory cytokines as an important switch to initiate adhesion [2]

Anatomical structures with this receptor

    Reference