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Details for receptor: G-protein coupled receptor GPCR33

EndoNet ID: ENR01338

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Synonyms

  • Gprc6a
  • G-protein coupled receptor family C group 6 member A
  • G-protein coupled receptor GPCR33

General information

  • Activated by extracellular calcium and osteocalcin. [1]

Links to other resources

UniProt Q5T6X5
Ensembl ENST00000530250

Subunit information

Sequence
MAFLIILIT CFVIILATS QPCQTPDDF 
VAATSPGHI IIGGLFAIH EKMLSSEDS 
PRRPQIQEC VGFEISVFL QTLAMIHSI 
EMINNSTLL PGVKLGYEI YDTCTEVTV 
AMAATLRFL SKFNCSRET VEFKCDYSS 
YMPRVKAVI GSGYSEITM AVSRMLNLQ 
LMPQVGYES TAEILSDKI RFPSFLRTV 
PSDFHQIKA MAHLIQKSG WNWIGIITT 
DDDYGRLAL NTFIIQAEA NNVCIAFKE 
VLPAFLSDN TIEVRINRT LKKIILEAQ 
VNVIVVFLR QFHVFDLFN KAIEMNINK 
MWIASDNWS TATKITTIP NVKKIGKVV 
GFAFRRGNI SSFHSFLQN LHLLPSDSH 
KLLHEYAMH LSACAYVKD TDLSQCIFN 
HSQRTLAYK ANKAIERNF VMRNDFLWD 
YAEPGLIHS IQLAVFALG YAIRDLCQA 
RDCQNPNAF QPWELLGVL KNVTFTDGW 
NSFHFDAHG DLNTGYDVV LWKEINGHM 
TVTKMAEYD LQNDVFIIP DQETKNEFR 
NLKQIQSKC SKECSPGQM KKTTRSQHI 
CCYECQNCP ENHYTNQTD MPHCLLCNN 
KTHWAPVRS TMCFEKEVE YLNWNDSLA 
ILLLILSLL GIIFVLVVG IIFTRNLNT 
PVVKSSGGL RVCYVILLC HFLNFASTS 
FFIGEPQDF TCKTRQTMF GVSFTLCIS 
CILTKSLKI LLAFSFDPK LQKFLKCLY 
RPILIIFTC TGIQVVICT LWLIFAAPT 
VEVNVSLPR VIILECEEG SILAFGTML 
GYIAILAFI CFIFAFKGK YENYNEAKF 
ITFGMLIYF IAWITFIPI YATTFGKYV 
PAVEIIVIL ISNYGILYC TFIPKCYVI 
ICKQEINTK SAFLKMIYS YSSHSVSSI 
ALSPASLDS MSGNVTMTN PSSSGKSAT 
WQKSKDLQA QAFAHICRE NATSVSKTL 
PRKRMSSI

Binding hormones

  • osteocalcin
    • CREB Is a Transcriptional Effector of Osteocalcin Signaling in Leydig Cells [2]

Anatomical structures with this receptor

  • Leydig_cell_of_testis

    Influences

    • positive testosterone
      • Osteocalcin favors male fertility is by increasing testosterone synthesis in Leydig cells. Testosterone, in turn, supports maturation and prevents apoptosis of germ cells [3]
    • These data identify Gprc6a as an osteocalcin receptor in Leydig cells. [2]
Reference