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Details for receptor: Putative tumor suppressor protein EXTL3

EndoNet ID: ENR01339

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  • Hereditary multiple exostoses gene isolog
  • Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
  • EXT-related protein 1
  • Putative tumor suppressor protein EXTL3
  • Multiple exostosis-like protein 3
  • Exostosin-like 3
  • EXTL3

General information

  • EXTL3 is thought to belong to the exostosin tumor (EXT) family because it shows homology with the C-terminal regions of EXT2 and EXT1 [1]
  • The N-terminal region of EXTL3, which has no homology with any other member, contains the membrane-spanning domain and the Reg binding domain. [1]

Links to other resources

UniProt O43909
Ensembl ENST00000220562

Binding hormones

  • REG1A
    • Kobayashi et al. isolated a Reg receptor, EXTL3. [1]

Anatomical structures with this receptor

  • neuron

    Induced phenotypes

    • neurite elongation
      • Here, we show that Reg-1α co-localizes with EXTL3 at the cell membrane of neuronal cells, and we demonstrate that the effects of Reg-1α on neurite elongation are mediated at least in part through this receptor. [1]
    • Here, we show that Reg-1α co-localizes with EXTL3 at the cell membrane of neuronal cells. [1]
  • beta_cell_of_islet_of_Langerhans

    Induced phenotypes

    • regeneration of beta-cells of pancreas
      • A Reg receptor, EXTL3, mediates the Reg growth signal for β-cell regeneration. [1]
    • EXTL3 was identified as the Reg-1α receptor involved in the regulation of pancreatic β-cells for maintaining the β-cell mass [1]
  • brain

    • However, EXTL3 is also expressed in other tissues, such as brain. [1]