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Details for receptor: Programmed cell death protein 1

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EndoNet ID: ENR01340

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Synonyms

  • PDCD1
  • Protein PD-1
  • hPD-1
  • CD279
  • Programmed cell death protein 1

General information

  • PD-1 is a member of the CD28 superfamily of immunoreceptors involved in regulating T cell activation. [1]
  • PD-1 is a 55kDa type I transmembrane protein that is upregulated on T cells, B cells, and some myeloid cells upon activation. [1]

Links to other resources

UniProt Q15116
Ensembl ENST00000334409

Subunit information

Sequence 
MQIPQAPWP VVWAVLQLG WRPGWFLDS 
PDRPWNPPT FSPALLVVT EGDNATFTC 
SFSNTSESF VLNWYRMSP SNQTDKLAA 
FPEDRSQPG QDCRFRVTQ LPNGRDFHM 
SVVRARRND SGTYLCGAI SLAPKAQIK 
ESLRAELRV TERRAEVPT AHPSPSPRP 
AGQFQTLVV GVVGGLLGS LVLLVWVLA 
VICSRAARG TIGARRTGQ PLKEDPSAV 
PVFSVDYGE LDFQWREKT PEPPVPCVP 
EQTEYATIV FPSGMGTSS PARRGSADG 
PRSAQPLRP EDGHCSWPL

Binding hormones

  • PD-L1
    • D-1 interacts with at least two ligands, programmed death-ligand 1 (PD-L1, CD274) and another closely related molecule, PD-L2 (CD273). [1]
  • PD-L2
    • D-1 interacts with at least two ligands, programmed death-ligand 1 (PD-L1, CD274) and another closely related molecule, PD-L2 (CD273). [1]

Anatomical structures with this receptor

  • B-lymphocyte

    Induced phenotypes

    • Supression of autoreactive B-lymphocytes
      • PD-1 was identified as the main suppressor of auto-Ab formation (by autoreactive B-cells). [2]
      • We found that B-cells needed to express PD-1 and that T(regulatory)-cells needed to express PD-1 ligands, implying direct communication between T(regs) and B-cells. [2]
    • PD-1 is a 55kDa type I transmembrane protein that is upregulated on B cells. [1]
Reference