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Details for receptor: PTPRB

EndoNet ID: ENR01343

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  • Receptor-type tyrosine-protein phosphatase beta
  • Protein-tyrosine phosphatase beta
  • R-PTP-beta
  • Vascular endothelial protein tyrosine phosphatase

General information

  • RPTPβ/ζ is a transmembrane tyrosine phosphatase, which is composed of a cytosoplasmic portion that carries protein tyrosine phosphatase activity, a transmembrane region, and an extracellular domain containing chondroitin sulfate for ligand binding. [1]

Links to other resources

UniProt P23467
Ensembl ENST00000368226

Binding hormones

  • PTN
    • PTN is identified as the first natural ligand for the transmembrane tyrosine phosphatase receptor. [1]
  • MK
    • PTPRB is the most established component of the MK receptor. [2]

Anatomical structures with this receptor

  • central_nerve_system_element

    Induced phenotypes

    • neuronal migration
      • We further demonstrated that pleiotrophin-induced neurite outgrowth and neuronal migration were suppressed by chondroitin sulfate, polyclonal antibodies against the extracellular domain of PTPζ, and sodium vanadate, a protein-tyrosine phosphatase inhibitor. [3]
    • PTPζ/RPTPβ1 is a receptor-like protein-tyrosine phosphatase, which is abundantly expressed in the central nervous system as a chondroitin sulfate proteoglycan. [3]