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Details for receptor: integrin alpha-IIb/beta-3

EndoNet ID: ENR01344

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Synonyms

  • integrin alpha-IIb/beta-3

General information

  • Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, vitronectin and von Willebrand factor. [1]

Links to other resources

Subunit information

Integrin alpha-IIb

Sequence
MARALCPLQ ALWLLEWVL LLLGPCAAP 
PAWALNLDP VQLTFYAGP NGSQFGFSL 
DFHKDSHGR VAIVVGAPR TLGPSQEET 
GGVFLCPWR AEGGQCPSL LFDLRDETR 
NVGSQTLQT FKARQGLGA SVVSWSDVI 
VACAPWQHW NVLEKTEEA EKTPVGSCF 
LAQPESGRR AEYSPCRGN TLSRIYVEN 
DFSWDKRYC EAGFSSVVT QAGELVLGA 
PGGYYFLGL LAQAPVADI FSSYRPGIL 
LWHVSSQSL SFDSSNPEY FDGYWGYSV 
AVGEFDGDL NTTEYVVGA PTWSWTLGA 
VEILDSYYQ RLHRLRGEQ MASYFGHSV 
AVTDVNGDG RHDLLVGAP LYMESRADR 
KLAEVGRVY LFLQPRGPH ALGAPSLLL 
TGTQLYGRF GSAIAPLGD LDRDGYNDI 
AVAAPYGGP SGRGQVLVF LGQSEGLRS 
RPSQVLDSP FPTGSAFGF SLRGAVDID 
DNGYPDLIV GAYGANQVA VYRAQPVVK 
ASVQLLVQD SLNPAVKSC VLPQTKTPV 
SCFNIQMCV GATGHNIPQ KLSLNAELQ 
LDRQKPRQG RRVLLLGSQ QAGTTLNLD 
LGGKHSPIC HTTMAFLRD EADFRDKLS 
PIVLSLNVS LPPTEAGMA PAVVLHGDT 
HVQEQTRIV LDCGEDDVC VPQLQLTAS 
VTGSPLLVG ADNVLELQM DAANEGEGA 
YEAELAVHL PQGAHYMRA LSNVEGFER 
LICNQKKEN ETRVVLCEL GNPMKKNAQ 
IGIAMLVSV GNLEEAGES VSFQLQIRS 
KNSQNPNSK IVLLDVPVR AEAQVELRG 
NSFPASLVV AAEEGEREQ NSLDSWGPK 
VEHTYELHN NGPGTVNGL HLSIHLPGQ 
SQPSDLLYI LDIQPQGGL QCFPQPPVN 
PLKVDWGLP IPSPSPIHP AHHKRDRRQ 
IFLPEPEQP SRLQDPVLV SCDSAPCTV 
VQCDLQEMA RGQRAMVTV LAFLWLPSL 
YQRPLDQFV LQSHAWFNV SSLPYAVPP 
LSLPRGEAQ VWTQLLRAL EERAIPIWW 
VLVGVLGGL LLLTILVLA MWKVGFFKR 
NRPPLEEDD EEGE
UniProt P08514

integrin beta-3

Sequence
MRARPRPRP LWATVLALG ALAGVGVGG 
PNICTTRGV SSCQQCLAV SPMCAWCSD 
EALPLGSPR CDLKENLLK DNCAPESIE 
FPVSEARVL EDRPLSDKG SGDSSQVTQ 
VSPQRIALR LRPDDSKNF SIQVRQVED 
YPVDIYYLM DLSYSMKDD LWSIQNLGT 
KLATQMRKL TSNLRIGFG AFVDKPVSP 
YMYISPPEA LENPCYDMK TTCLPMFGY 
KHVLTLTDQ VTRFNEEVK KQSVSRNRD 
APEGGFDAI MQATVCDEK IGWRNDASH 
LLVFTTDAK THIALDGRL AGIVQPNDG 
QCHVGSDNH YSASTTMDY PSLGLMTEK 
LSQKNINLI FAVTENVVN LYQNYSELI 
PGTTVGVLS MDSSNVLQL IVDAYGKIR 
SKVELEVRD LPEELSLSF NATCLNNEV 
IPGLKSCMG LKIGDTVSF SIEAKVRGC 
PQEKEKSFT IKPVGFKDS LIVQVTFDC 
DCACQAQAE PNSHRCNNG NGTFECGVC 
RCGPGWLGS QCECSEEDY RPSQQDECS 
PREGQPVCS QRGECLCGQ CVCHSSDFG 
KITGKYCEC DDFSCVRYK GEMCSGHGQ 
CSCGDCLCD SDWTGYYCN CTTRTDTCM 
SSNGLLCSG RGKCECGSC VCIQPGSYG 
DTCEKCPTC PDACTFKKE CVECKKFDR 
GALHDENTC NRYCRDEIE SVKELKDTG 
KDAVNCTYK NEDDCVVRF QYYEDSSGK 
SILYVVEEP ECPKGPDIL VVLLSVMGA 
ILLIGLAAL LIWKLLITI HDRKEFAKF 
EEERARAKW DTANNPLYK EATSTFTNI 
TYRGT
UniProt P05106

Binding hormones

  • von Willebrand factor
    • Physiologically, the integrin GPIIb/IIIa binds Von Willebrand factor and fibrinogen on activated platelets. [2]
  • fibrinogen
    • Physiologically, the integrin GPIIb/IIIa binds Von Willebrand factor and fibrinogen on activated platelets. [2]

Anatomical structures with this receptor

    Reference