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Details for receptor: G-CSF-R

EndoNet ID: ENR01346

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Synonyms

  • CSF3R
  • GCSFR
  • G-CSF receptor
  • G-CSF-R
  • CD114
  • Granulocyte colony-stimulating factor receptor

General information

  • Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. [1]
  • G-CSFR is a transmembrane protein with a structure typical of the type I cytokine receptor family. [2]

Links to other resources

UniProt Q99062
Ensembl ENST00000440588

Subunit information

Sequence
MARLGNCSL TWAALIILL LPGSLEECG 
HISVSAPIV HLGDPITAS CIIKQNCSH 
LDPEPQILW RLGAELQPG GRQQRLSDG 
TQESIITLP HLNHTQAFL SCCLNWGNS 
LQILDQVEL RAGYPPAIP HNLSCLMNL 
TTSSLICQW EPGPETHLP TSFTLKSFK 
SRGNCQTQG DSILDCVPK DGQSHCCIP 
RKHLLLYQN MGIWVQAEN ALGTSMSPQ 
LCLDPMDVV KLEPPMLRT MDPSPEAAP 
PQAGCLQLC WEPWQPGLH INQKCELRH 
KPQRGEASW ALVGPLPLE ALQYELCGL 
LPATAYTLQ IRCIRWPLP GHWSDWSPS 
LELRTTERA PTVRLDTWW RQRQLDPRT 
VQLFWKPVP LEEDSGRIQ GYVVSWRPS 
GQAGAILPL CNTTELSCT FHLPSEAQE 
VALVAYNSA GTSRPTPVV FSESRGPAL 
TRLHAMARD PHSLWVGWE PPNPWPQGY 
VIEWGLGPP SASNSNKTW RMEQNGRAT 
GFLLKENIR PFQLYEIIV TPLYQDTMG 
PSQHVYAYS QEMAPSHAP ELHLKHIGK 
TWAQLEWVP EPPELGKSP LTHYTIFWT 
NAQNQSFSA ILNASSRGF VLHGLEPAS 
LYHIHLMAA SQAGATNST VLTLMTLTP 
EGSELHIIL GLFGLLLLL TCLCGTAWL 
CCSPNRKNP LWPSVPDPA HSSLGSWVP 
TIMEEDAFQ LPGLGTPPI TKLTVLEED 
EKKPVPWES HNSSETCGL PTLVQTYVL 
QGDPRAVST QPQSQSGTS DQVLYGQLL 
GSPTSPGPG HYLRCDSTQ PLLAGLTPS 
PKSYENLWF QASPLGTLV TPAPSQEDD 
CVFGPLLNF PLLQGIRVH GMEALGSF

Binding hormones

  • G-CSF
    • All cellular responses to G-CSF are the consequence of signals arising from the G-CSF receptor. [2]

Anatomical structures with this receptor

  • neutrophil_granulocyte

    Induced phenotypes

    • regulation of neutrophil production
      • G-CSF plays a role in neutrophil production via its receptor G-CSFR. [2]
    • The G-CSFR is expressed by all neutrophils and their precursors. [2]
Reference