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Details for receptor: Prokineticin receptor 1

EndoNet ID: ENR01347

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  • G-protein coupled receptor 73
  • Prokineticin receptor 1
  • GPR73a
  • G-protein coupled receptor ZAQ

General information

  • Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. [1]

Links to other resources

UniProt Q8TCW9

Binding hormones

    • The prokineticin receptor 1 (PROKR1) and the prokineticin receptor 2 (PROKR2) are able to bind PROK1 and PROK2 with similar affinities. [2]

Anatomical structures with this receptor

  • cell_of_endometrium_of_uterus


    • positive IL-11
      • In the present study, we report that PROK1 induces the expression and secretion of the cytokine IL-11 in cultured endometrial epithelial cells and first trimester decidua explants via the PK-1 receptor. [2]
    • PROKR1 localizes to the glandular and luminal epithelium, endothelial, and stromal cells in the functional layer of the endometrium [3]