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Details for receptor: Klotho beta-like protein

EndoNet ID: ENR01348

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Synonyms

  • Klotho beta-like protein
  • Beta-klotho

General information

  • The βklotho gene encodes a single-pass transmembrane protein expressed in adipose tissue, liver, and pancreas. [1]

Links to other resources

UniProt Q86Z14
Ensembl ENST00000257408

Subunit information

main chain

Sequence
MKPGCAAGS PGNEWIFFS TDEITTRYR 
NTMSNGGLQ RSVILSALI LLRAVTGFS 
GDGRAIWSK NPNFTPVNE SQLFLYDTF 
PKNFFWGIG TGALQVEGS WKKDGKGPS 
IWDHFIHTH LKNVSSTNG SSDSYIFLE 
KDLSALDFI GVSFYQFSI SWPRLFPDG 
IVTVANAKG LQYYSTLLD ALVLRNIEP 
IVTLYHWDL PLALQEKYG GWKNDTIID 
IFNDYATYC FQMFGDRVK YWITIHNPY 
LVAWHGYGT GMHAPGEKG NLAAVYTVG 
HNLIKAHSK VWHNYNTHF RPHQKGWLS 
ITLGSHWIE PNRSENTMD IFKCQQSMV 
SVLGWFANP IHGDGDYPE GMRKKLFSV 
LPIFSEAEK HEMRGTADF FAFSFGPNN 
FKPLNTMAK MGQNVSLNL REALNWIKL 
EYNNPRILI AENGWFTDS RVKTEDTTA 
IYMMKNFLS QVLQAIRLD EIRVFGYTA 
WSLLDGFEW QDAYTIRRG LFYVDFNSK 
QKERKPKSS AHYYKQIIR ENGFSLKES 
TPDVQGQFP CDFSWGVTE SVLKPESVA 
SSPQFSDPH LYVWNATGN RLLHRVEGV 
RLKTRPAQC TDFVNIKKQ LEMLARMKV 
THYRFALDW ASVLPTGNL SAVNRQALR 
YYRCVVSEG LKLGISAMV TLYYPTHAH 
LGLPEPLLH ADGWLNPST AEAFQAYAG 
LCFQELGDL VKLWITINE PNRLSDIYN 
RSGNDTYGA AHNLLVAHA LAWRLYDRQ 
FRPSQRGAV SLSLHADWA EPANPYADS 
HWRAAERFL QFEIAWFAE PLFKTGDYP 
AAMREYIAS KHRRGLSSS ALPRLTEAE 
RRLLKGTVD FCALNHFTT RFVMHEQLA 
GSRYDSDRD IQFLQDITR LSSPTRLAV 
IPWGVRKLL RWVRRNYGD MDIYITASG 
IDDQALEDD RLRKYYLGK YLQEVLKAY 
LIDKVRIKG YYAFKLAEE KSKPRFGFF 
TSDFKAKSS IQFYNKVIS SRGFPFENS 
SSRCSQTQE NTECTVCLF LVQKKPLIF 
LGCCFFSTL VLLLSIAIF QRQKRRKFW 
KAKNLQHIP LKKGKRVVS

Binding hormones

  • FGF-21
    • The C-terminus of FGF21 is involved in the direct interaction with βKlotho adaptor protein. [2]
  • FGF-19
    • FGF15/19 requires βKlotho as a coreceptor. [1]

Anatomical structures with this receptor

    Reference