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Details for receptor: alpha-Klotho

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EndoNet ID: ENR01349

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Synonyms

  • alpha-Klotho

General information

  • The five exons of αklotho gene encode a single pass, type I transmembrane, and β-glycosidase-like protein with β-glucuronidase activity. The αklotho protein shares 41% amino acid identity with βklotho. [1]
  • Two soluble species have also been reported, an alternatively spliced secreted form (sKL) (exons 1–3 of the 5-exon KL gene) and an endoproteolytic cleavage product of mKL (cKL). [2]

Links to other resources

UniProt Q9UEF7
Ensembl ENST00000380099

Subunit information

Sequence 
MPASAPPRR PRPPPPSLS LLLVLLGLG 
GRRLRAEPG DGAQTWARF SRPPAPEAA 
GLFQGTFPD GFLWAVGSA AYQTEGGWQ 
QHGKGASIW DTFTHHPLA PPGDSRNAS 
LPLGAPSPL QPATGDVAS DSYNNVFRD 
TEALRELGV THYRFSISW ARVLPNGSA 
GVPNREGLR YYRRLLERL RELGVQPVV 
TLYHWDLPQ RLQDAYGGW ANRALADHF 
RDYAELCFR HFGGQVKYW ITIDNPYVV 
AWHGYATGR LAPGIRGSP RLGYLVAHN 
LLLAHAKVW HLYNTSFRP TQGGQVSIA 
LSSHWINPR RMTDHSIKE CQKSLDFVL 
GWFAKPVFI DGDYPESMK NNLSSILPD 
FTESEKKFI KGTADFFAL CFGPTLSFQ 
LLDPHMKFR QLESPNLRQ LLSWIDLEF 
NHPQIFIVE NGWFVSGTT KRDDAKYMY 
YLKKFIMET LKAIKLDGV DVIGYTAWS 
LMDGFEWHR GYSIRRGLF YVDFLSQDK 
MLLPKSSAL FYQKLIEKN GFPPLPENQ 
PLEGTFPCD FAWGVVDNY IQVDTTLSQ 
FTDLNVYLW DVHHSKRLI KVDGVVTKK 
RKSYCVDFA AIQPQIALL QEMHVTHFR 
FSLDWALIL PLGNQSQVN HTILQYYRC 
MASELVRVN ITPVVALWQ PMAPNQGLP 
RLLARQGAW ENPYTALAF AEYARLCFQ 
ELGHHVKLW ITMNEPYTR NMTYSAGHN 
LLKAHALAW HVYNEKFRH AQNGKISIA 
LQADWIEPA CPFSQKDKE VAERVLEFD 
IGWLAEPIF GSGDYPWVM RDWLNQRNN 
FLLPYFTED EKKLIQGTF DFLALSHYT 
TILVDSEKE DPIKYNDYL EVQEMTDIT 
WLNSPSQVA VVPWGLRKV LNWLKFKYG 
DLPMYIISN GIDDGLHAE DDQLRVYYM 
QNYINEALK AHILDGINL CGYFAYSFN 
DRTAPRFGL YRYAADQFE PKASMKHYR 
KIIDSNGFP GPETLERFC PEEFTVCTE 
CSFFHTRKS LLAFIAFLF FASIISLSL 
IFYYSKKGR RSYK

Binding hormones

  • FGF-23
    • Subsequent studies have identified αKlotho as being the necessary coreceptor for FGF23. [1]

Anatomical structures with this receptor

  • choroid_plexus_of_telencephalon

    • Klotho proteins were localized at choroid plexus in brain. [3]

  • distal_tubule_of_nephron

    • Klotho proteins were localized at distal renal tubules in kidney. [3]
Reference