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Details for receptor: Complement receptor 3

EndoNet ID: ENR01353

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Synonyms

  • Macrophage-1 antigen
  • Complement receptor 3
  • CD11b/CD18
  • integrin alphaMbeta2

General information

  • Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. [1]

Links to other resources

Subunit information

Integrin alpha-M

Sequence
FNLDTENAM TFQENARGF GQSVVQLQG 
SRVVVGAPQ EIVAANQRG SLYQCDYST 
GSCEPIRLQ VPVEAVNMS LGLSLAATT 
SPPQLLACG PTVHQTCSE NTYVKGLCF 
LFGSNLRQQ PQKFPEALR GCPQEDSDI 
AFLIDGSGS IIPHDFRRM KEFVSTVME 
QLKKSKTLF SLMQYSEEF RIHFTFKEF 
QNNPNPRSL VKPITQLLG RTHTATGIR 
KVVRELFNI TNGARKNAF KILVVITDG 
EKFGDPLGY EDVIPEADR EGVIRYVIG 
VGDAFRSEK SRQELNTIA SKPPRDHVF 
QVNNFEALK TIQNQLREK IFAIEGTQT 
GSSSSFEHE MSQEGFSAA ITSNGPLLS 
TVGSYDWAG GVFLYTSKE KSTFINMTR 
VDSDMNDAY LGYAAAIIL RNRVQSLVL 
GAPRYQHIG LVAMFRQNT GMWESNANV 
KGTQIGAYF GASLCSVDV DSNGSTDLV 
LIGAPHYYE QTRGGQVSV CPLPRGRAR 
WQCDAVLYG EQGQPWGRF GAALTVLGD 
VNGDKLTDV AIGAPGEED NRGAVYLFH 
GTSGSGISP SHSQRIAGS KLSPRLQYF 
GQSLSGGQD LTMDGLVDL TVGAQGHVL 
LLRSQPVLR VKAIMEFNP REVARNVFE 
CNDQVVKGK EAGEVRVCL HVQKSTRDR 
LREGQIQSV VTYDLALDS GRPHSRAVF 
NETKNSTRR QTQVLGLTQ TCETLKLQL 
PNCIEDPVS PIVLRLNFS LVGTPLSAF 
GNLRPVLAE DAQRLFTAL FPFEKNCGN 
DNICQDDLS ITFSFMSLD CLVVGGPRE 
FNVTVTVRN DGEDSYRTQ VTFFFPLDL 
SYRKVSTLQ NQRSQRSWR LACESASST 
EVSGALKST SCSINHPIF PENSEVTFN 
ITFDVDSKA SLGNKLLLK ANVTSENNM 
PRTNKTEFQ LELPVKYAV YMVVTSHGV 
STKYLNFTA SENTSRVMQ HQYQVSNLG 
QRSLPISLV FLVPVRLNQ TVIWDRPQV 
TFSENLSST CHTKERLPS HSDFLAELR 
KAPVVNCSI AVCQRIQCD IPFFGIQEE 
FNATLKGNL SFDWYIKTS HNHLLIVST 
AEILFNDSV FTLLPGQGA FVRSQTETK 
VEPFEVPNP LPLIVGSSV GGLLLLALI 
TAALYKLGF FKRQYKDMM SEGGPPGAE 
PQ
UniProt P11215

Integrin beta-2

Sequence
ECTKFKVSS CRECIESGP GCTWCQKLN 
FTGPGDPDS IRCDTRPQL LMRGCAADD 
IMDPTSLAE TQEDHNGGQ KQLSPQKVT 
LYLRPGQAA AFNVTFRRA KGYPIDLYY 
LMDLSYSML DDLRNVKKL GGDLLRALN 
EITESGRIG FGSFVDKTV LPFVNTHPD 
KLRNPCPNK EKECQPPFA FRHVLKLTN 
NSNQFQTEV GKQLISGNL DAPEGGLDA 
MMQVAACPE EIGWRNVTR LLVFATDDG 
FHFAGDGKL GAILTPNDG RCHLEDNLY 
KRSNEFDYP SVGQLAHKL AENNIQPIF 
AVTSRMVKT YEKLTEIIP KSAVGELSE 
DSSNVVQLI KNAYNKLSS RVFLDHNAL 
PDTLKVTYD SFCSNGVTH RNQPRGDCD 
GVQINVPIT FQVKVTATE CIQEQSFVI 
RALGFTDIV TVQVLPQCE CRCRDQSRD 
RSLCHGKGF LECGICRCD TGYIGKNCE 
CQTQGRSSQ ELEGSCRKD NNSIICSGL 
GDCVCGQCL CHTSDVPGK LIYGQYCEC 
DTINCERYN GQVCGGPGR GLCFCGKCR 
CHPGFEGSA CQCERTTEG CLNPRRVEC 
SGRGRCRCN VCECHSGYQ LPLCQECPG 
CPSPCGKYI SCAECLKFE KGPFGKNCS 
AACPGLQLS NNPVKGRTC KERDSEGCW 
VAYTLEQQD GMDRYLIYV DESRECVAG 
PNIAAIVGG TVAGIVLIG ILLLVIWKA 
LIHLSDLRE YRRFEKEKL KSQWNNDNP 
LFKSATTTV MNPKFAES
UniProt P05107

Binding hormones

  • HBP
    • The binding of HBP to polymorphonuclear neutrophils (PMN) is mediated by CD11/CD18 (complement receptor, CR3). [2]

Anatomical structures with this receptor

    Reference